CAJ | 학술논문

目的研究中国北方人群磺脲受体1(SUR1)基因24内含子-3t/c多态性与血脂的相关性.方法研究对象为132对2型糖尿病的病例对照和282个2型糖尿病家系.用聚合酶链反应(PCR)-长度多态性的方法检测磺脲受体1基因24内含子-3t/c多态性.统计方法采用t检验、多元线性回归和以家系为基础的相关性检验.结果在非糖尿病的对照人群中,SUR1基因24内含子-3t/c多态性cc基因型的总胆固醇(TC)、低密度脂蛋白(LDL)及载脂蛋白B(ApoB)水平均比tt型和tc型高.家系资料分析结果表明SUR1基因24内含子-3t/c多态性与TC、ApoB以及体重指数(BMI)等表型资料存在显著相关性.结论在中国北方地区人群中SUR1基因24内含子-3t/c多态性与TC、LDL和ApoB等血脂水平显著相关.
목적연구중국북방인군광뇨수체1(SUR1)기인24내함자-3t/c다태성여혈지적상관성.방법연구대상위132대2형당뇨병적병례대조화282개2형당뇨병가계.용취합매련반응(PCR)-장도다태성적방법검측광뇨수체1기인24내함자-3t/c다태성.통계방법채용t검험、다원선성회귀화이가계위기출적상관성검험.결과재비당뇨병적대조인군중,SUR1기인24내함자-3t/c다태성cc기인형적총담고순(TC)、저밀도지단백(LDL)급재지단백B(ApoB)수평균비tt형화tc형고.가계자료분석결과표명SUR1기인24내함자-3t/c다태성여TC、ApoB이급체중지수(BMI)등표형자료존재현저상관성.결론재중국북방지구인군중SUR1기인24내함자-3t/c다태성여TC、LDL화ApoB등혈지수평현저상관.
Obeject To study the association of sulfonylurea receptor (SUR) 1 gene and blood lipids level.Method We investigated the SUR1 gene intron 24 3t/c polymorphism by polymerase chain reaction (PCR) and appropriate restriction enzyme (PCR RFLP) in 132 couples of type 2 diabetic case control and 282 type 2 diabetic pedigrees. The statistical methods were t test, multiple line regression and family based association test (FBAT).Result In the control group, the level of total cholesterol (TC), low density lipoprotein (LDL) and Apo B were higher in the cc genotype than that in the tt and the tc genotype. FBAT showed that sulfonylurea receptor 1 gene intron 24 3t/c polymorphism was significantly associated with TC, ApoB and BMI.Conclusion Sulfonylurea receptor 1 gene intron 24 3t/c polymorphism is associated with blood lipid level in north Chinese population.