CAJ | 학술논문

目的研究大剂量环磷酰胺冲击治疗系统性红斑狼疮时的闭经危险。方法前瞻性对比研究51例接受大剂量环磷酰胺冲击治疗的生育期女性患者与22例接受甲基强的松龙治疗的生育期女性患者的闭经发生率及其规律。结果大剂量环磷酰胺冲击治疗组闭经率19.6%，比甲基强的松龙治疗组的闭经率明显增高（P=0.025）；大剂量环磷酰胺冲击治疗组中，年龄大于30岁组比30岁及30岁以下组闭经率高（P=0.0018）。结论大剂量环磷酰胺冲击治疗系统性红斑狼疮时，生育期女性患者闭经率升高。年龄愈大，闭经的危险愈高。
목적연구대제량배린선알충격치료계통성홍반랑창시적폐경위험。방법전첨성대비연구51례접수대제량배린선알충격치료적생육기녀성환자여22례접수갑기강적송룡치료적생육기녀성환자적폐경발생솔급기규률。결과대제량배린선알충격치료조폐경솔19.6%，비갑기강적송룡치료조적폐경솔명현증고（P=0.025）；대제량배린선알충격치료조중，년령대우30세조비30세급30세이하조폐경솔고（P=0.0018）。결론대제량배린선알충격치료계통성홍반랑창시，생육기녀성환자폐경솔승고。년령유대，폐경적위험유고。
Objective　To determine the risk of sustained amenorrhea in premenopausal women with systemic lupus erythematosus (SLE) receiving intermittent pulse cyclophosphamide (CTX) therapy. Methods　Prospectively comparing the amenorrhea rate of 51 cases receiving intermittent pulse cyclophosphamide therapy versus that of 22 cases receiving intermittent pulse methylprednisolone (MP) therapy. Results　The amenorrhea rate was higher in the CTX group (19.6%) than in the MP group (P=0.025).In the CTX group, the amenorrhea rate of patients aged over 30 was higher than that of patients aged 30 or below 30 (P=0.0018). Conclusion　Pulse CTX therapy in fertile women with SLE is associated with increased rate of sustained amenorrhea, and the older the patient is, the higher risk for sustained amenorrhea the patient runs.