北京医学
北京醫學
북경의학
BEIJING MEDICAL JOURNAL
2001年
1期
31-33
,共3页
白介素%急性胰腺炎
白介素%急性胰腺炎
백개소%급성이선염
目的 研究血清白介素6(IL-6)、白介素8(IL-8)水平在不同程度急性胰腺炎中的变化。方法 采用胰头及胰尾部实质内定点注射牛磺胆酸钠溶液的方法制造程度不同的大鼠急性胰腺炎(AP)模型，检测和分析血清IL-6和IL-8的水平。结果 坏死组血清IL-6、8明显增高，与对照组及水肿组有显著性差异。结论 在AP期间细胞因子参与机体的炎症反应，细胞因子的过度表达在重症急性胰腺炎的发病过程中起重要的作用，检测血清IL-6、IL-8浓度的变化可作为判断AP严重程度的指标。
目的 研究血清白介素6(IL-6)、白介素8(IL-8)水平在不同程度急性胰腺炎中的變化。方法 採用胰頭及胰尾部實質內定點註射牛磺膽痠鈉溶液的方法製造程度不同的大鼠急性胰腺炎(AP)模型，檢測和分析血清IL-6和IL-8的水平。結果 壞死組血清IL-6、8明顯增高，與對照組及水腫組有顯著性差異。結論 在AP期間細胞因子參與機體的炎癥反應，細胞因子的過度錶達在重癥急性胰腺炎的髮病過程中起重要的作用，檢測血清IL-6、IL-8濃度的變化可作為判斷AP嚴重程度的指標。
목적 연구혈청백개소6(IL-6)、백개소8(IL-8)수평재불동정도급성이선염중적변화。방법 채용이두급이미부실질내정점주사우광담산납용액적방법제조정도불동적대서급성이선염(AP)모형，검측화분석혈청IL-6화IL-8적수평。결과 배사조혈청IL-6、8명현증고，여대조조급수종조유현저성차이。결론 재AP기간세포인자삼여궤체적염증반응，세포인자적과도표체재중증급성이선염적발병과정중기중요적작용，검측혈청IL-6、IL-8농도적변화가작위판단AP엄중정도적지표。
Objective To evaluate the variance of serum interleukin-6 and interleukin-8 in acute pancreatitis rats.Methods The rat acute pancreatitis model was induced by sodium taurocholate.The levels of the serum IL-6 and IL-8 were measured and analysed.Results We found that the levels of serum IL-6 and IL-8 were significantly higher in the acute necrosis pancreatitis group compared with other groups,but there were no differences between the acute dropsical pancreatitis group and the control group.Conclusions The level of the inflammatory medium has closed relativity with the severity of acute pancreatitis.We can evaluate the severity of acute parcreatitis by testing the level of serum IL-6 and IL-8.We can also tell the prognosis of the disease according to the changes of serum IL-6 and IL-8.
