CAJ | 학술논문

采用新生态Cu(Ⅰ)催化碘同位素交换反应制备了123I-BMIPP。经高效液相色谱法分离纯化，产品放射化学纯度>95%，放化产率为30%40%，经细菌检验、热原检验证明无菌、无热原。动物体内分布显示心肌摄取123I-BMIPP快速、存留时间长，与周围临近组织的放射性比值高，适合于SPECT代谢显像。
채용신생태Cu(Ⅰ)최화전동위소교환반응제비료123I-BMIPP。경고효액상색보법분리순화，산품방사화학순도>95%，방화산솔위30%40%，경세균검험、열원검험증명무균、무열원。동물체내분포현시심기섭취123I-BMIPP쾌속、존류시간장，여주위림근조직적방사성비치고，괄합우SPECT대사현상。
123I labeled side chain fatty acid BMIPP (123I-BMIPP) was prepa red by isotopic exchange using Cu(I) as catalyst in an alcohol water mixtu re. The radiochemical purity of 123I-BMIPP was >95%, and the verall radio chemical yield was 30%40%. In mice, the myocardum uptake was about 8% of injected dose. 123I-BMIPP is a suitable agent for myocardial fatty acid metabolism imaging