CAJ | 학술논문

目的探讨糖尿病胃肠功能紊乱大鼠胃肠道自主神经病变的靶位. 方法应用四氧嘧啶-糖尿病大鼠模型,对其胃肠道多个部位的β2-肾上腺素能受体(β2-AR)与5-羟色胺受体(5-HTR)的数量进行免疫组化检测. 结果糖尿病大鼠胃窦与结肠的5-HTR显著增多;糖尿病大鼠黏膜内分泌细胞的β2-AR在肠道均有减少. 结论胃肠道的β2-AR与5-HTR的数量在糖尿病胃肠功能紊乱时发生了改变,这种改变很可能是糖尿病胃肠功能紊乱的发病基础.
목적탐토당뇨병위장공능문란대서위장도자주신경병변적파위. 방법응용사양밀정-당뇨병대서모형,대기위장도다개부위적β2-신상선소능수체(β2-AR)여5-간색알수체(5-HTR)적수량진행면역조화검측. 결과당뇨병대서위두여결장적5-HTR현저증다;당뇨병대서점막내분비세포적β2-AR재장도균유감소. 결론위장도적β2-AR여5-HTR적수량재당뇨병위장공능문란시발생료개변,저충개변흔가능시당뇨병위장공능문란적발병기출.
Objective To clarify the autonomic nerve d isorder of gastrointestinal tract in diabetic rat with gastrointestinal dysf unction. Methods Diabetic SD rats aged at 12 weeks were rand omly divided into two groups: group A(diabetic), group B(control). Using allox an-prepared diabetic rat model with gastrointestinal dysfunction, the quantity of β 2-adrenergic receptor(β 2-AR) and serotonin receptor(5-HTR) of the g astrointestinal tract were detected by immunohistochemical stain. Resul ts The quantity of 5-HTR in myenteric nerve plexus at gastric antr um and colon were increased (χ2=26.40, P<0.01; χ2=11.01, P<0.01, sepa rately). The quantity of β 2-AR of mucous membrane and myenteron at small int estine and bowel in diabetic rats were all decreased (χ2=11.40, P<0.01; χ 2=7.71, P<0.01; χ2=27.81, P<0.01; χ2=18.71, P<0.05, separately). Conclusions The quantity of β 2-AR and 5-HTR in gastrointest inal tract are changed in rat with diabetic gastrointestinal dysfunction. these changes may be the pathogenesis foundations.