CAJ | 학술논문

目的:研究直肠肿瘤发生血管转移的机制.方法:选取8例直肠腺癌患者的癌周组织和淋巴结,6例正常人的直肠组织和淋巴结,用免疫组化sp法处理标本.结果:癌周直肠组织及癌周淋巴结中的血管内皮细胞内,均有ICAM-1和CEA的强表达.癌周直肠组织中及癌周淋巴结中的血管内皮细胞内,均有CD31的表达;而正常对照组直肠组织和淋巴结中血管内皮细胞亦见CD31的表达,表达的强度相同.结论:研究表明ICAM-1和CEA在癌细胞和内皮细胞之间可能起到一定的粘附作用,而CD31在癌细胞和内皮细胞之间作用还不是十分清楚.
목적:연구직장종류발생혈관전이적궤제.방법:선취8례직장선암환자적암주조직화림파결,6례정상인적직장조직화림파결,용면역조화sp법처리표본.결과:암주직장조직급암주림파결중적혈관내피세포내,균유ICAM-1화CEA적강표체.암주직장조직중급암주림파결중적혈관내피세포내,균유CD31적표체;이정상대조조직장조직화림파결중혈관내피세포역견CD31적표체,표체적강도상동.결론:연구표명ICAM-1화CEA재암세포화내피세포지간가능기도일정적점부작용,이CD31재암세포화내피세포지간작용환불시십분청초.
Objective:In order to study mechanism of hematogenous metastasis of rectum cancer.Methods:8 specimens of human rectum cancer and 6 specimens of rectum in normal human were examined.The immunohistochemical SP method was employed in study of the expression of ICAM1,CEA and CD31 in the peritumoral rectum tissues and lymphy nodes.Results:The intercellular role in the adhesion molecule-1(ICAM-1)and carcinoma embryonic antigen(CEA) were expressed on the vascular endothelial cells of peritumoral rectum tissues and peritumoral lymph nodes in the rectum cancer.CD31 are expressed on the vascular endothelial cells of rectum tissues from normal human with the same intensity of cancer peritumoral rectum tissues.Conclusion:This study showed that ICAM-1 and CEA seemed to play a stable role in the adhesion effect between cancer cells and endothelial cells.It is not clear whether CD31 plays a role in the interaction between cancer cells and endothelial cells.