CAJ | 학술논문

利用可聚合乳化剂(12-丙烯酰氧基-9-十八烯酸,AOA),在反相乳液中进行辐射原位界面聚合,成功制备出聚苯乙烯药物胶囊.自由基引发AOA与苯乙烯在油水界面进行聚合,胶囊的壁厚与油相苯乙烯单体浓度成正比.同时,通过包裹水杨酸钠进行了药物释放试验研究.在反相乳液中,原位界面聚合可以实现简单、高效的一步法制备聚合物中空微球/胶囊.
이용가취합유화제(12-병희선양기-9-십팔희산,AOA),재반상유액중진행복사원위계면취합,성공제비출취분을희약물효낭.자유기인발AOA여분을희재유수계면진행취합,효낭적벽후여유상분을희단체농도성정비.동시,통과포과수양산납진행료약물석방시험연구.재반상유액중,원위계면취합가이실현간단、고효적일보법제비취합물중공미구/효낭.
Polymerizable surfactant (12-acryloxy-9-octadecenoic acid, AOA) was introduced intoinverse emulsion to control the in-situ interracial polymerization induced by 60 Co γ-ray andpolystyrene microcapsules were successfully synthesized. Free-radical polymerization wasconstrained to the interface of water-in-oil emulsion by the copolymerization of AOA and styrene.The shell thickness can be controlled by monomer content, The hydrophobic hollow microsphereswere used to encapsulate a large amount of sodium salicylate directly and the controlled release ofthe drug into water at a tunable rate depended on the shell thickness. This study demonstratesthe potential of hollow microspheres, prepared from 60 Co y-ray induced in-situ interracialpolymerization, as drug carriers in controlled drug release applications.