CAJ | 학술논문

目的探讨兔早期急性肺栓塞(APE)后肺动脉高压(PHT)状态下E指数、M指数的变化及意义.方法建立有PHT的兔APE模型,常规超声心动图及组织多普勒成像(TDI)检测栓塞前、后的二尖瓣舒张早期速度E峰(EM)、舒张晚期速度A峰(AM)等多项参数,计算E指数、M指数,并比较栓塞前后的变化.结果成功建立兔APE模型23只,3只兔因房颤未纳入研究.APE后肺动脉压力明显增高,EM明显减低,右心室心肌做功指数较左心室心肌做功指数增大明显.E指数明显减低,M指数明显增大.结论 APE后E指数及M指数的改变可能为定量评价早期APE提供新的参考依据.
목적 탐토토조기급성폐전새(APE)후폐동맥고압(PHT)상태하E지수、M지수적변화급의의.방법 건립유PHT적토APE모형,상규초성심동도급조직다보륵성상(TDI)검측전새전、후적이첨판서장조기속도E봉(EM)、서장만기속도A봉(AM)등다항삼수,계산E지수、M지수,병비교전새전후적변화.결과 성공건립토APE모형23지,3지토인방전미납입연구.APE후폐동맥압력명현증고,EM명현감저,우심실심기주공지수교좌심실심기주공지수증대명현.E지수명현감저,M지수명현증대.결론 APE후E지수급M지수적개변가능위정량평개조기APE제공신적삼고의거.
Objective To explore the variation of E-index and M-index of rabbits with acute pulmonary embolism (APE) under the status of pulmonary hypertension (PHT). Methods Rabbit models of APE with PHT were established. A series of parameters [including peak early diastolic mitral inflow velocity (EM), peak late diastolic mitral inflow velocity (AM) and so on] were obtained with routine echocardiography and tissue Doppler imaging (TDI);and then E-index, M-index were calculated. The parameters before and after APE were compared. Results Twenty-three rabbit models with APE were successfully established, but 3 with atrial fibrillation were excluded. After APE, pulmonary artery pressure increased significantly, EM decreased observably, whereas right ventricular myocardial performance index (RVMPI) increased more evidently than left ventricular myocardial performance index (LVMPI) (P<0.01) did and E-index decreased and M-index increased remarkably. Conclusion Changes of E-index and M-index may provide reference for quantitative assessment of early APE.