CAJ | 학술논문

目的探讨趋化因子受体7(CXCR7)蛋白在膀胱癌中的表达情况,并分析其与临床生物学行为及复发的关系.方法选择148例膀胱移行细胞癌标本,30例正常膀胱组织标本:肿瘤标本中非肌层浸润性癌104例,肌层浸润性癌44例;G147例、G2 73例、G3 28例;单发肿瘤89例,多发肿瘤59例;非肌层浸润性癌中未复发40例,复发64例.采用LSAB免疫组织化学方法,检测膀胱癌和正常组织中CXCR7蛋白的表达,并结合临床资料进行分析. 结果正常组织中CXCR7蛋白的表达水平为10.0%(3/30),肿瘤组织为85.1%(126/148);单发及多发肿瘤CXCR7蛋白高表达率分别为49.4%(44/89)和71.2%(42/59),G1、G2、G3膀胱癌CXCR7蛋白高表达阳性率分别为34.0%(16/47)、65.8%(48/73)、78.6%(22/28),差异均有统计学意义(P＜0.01).非肌层浸润性肿瘤和肌层浸润性肿瘤中CXCR7蛋白高表达阳性率为51.9%和72.7%,组间差异有统计学意义(P＜0.05).非肌层浸润性膀胱癌中,复发组与未复发组中CXCR7蛋白高表达阳性率为64.1%和32.5%,差异有统计学意义(P＜0.01).Kaplan-Merier曲线显示,CXCR7蛋白高表达组患者和CXCR7蛋白低表达组患者术后无复发生存率比较,差异有统计学意义(P＜0.01). 结论CXCR7蛋白高表达与膀胱移行细胞癌的恶性程度及预后相关,提示CXCR7与膀胱癌的发生发展存在相关性.
목적 탐토추화인자수체7(CXCR7)단백재방광암중적표체정황,병분석기여림상생물학행위급복발적관계.방법 선택148례방광이행세포암표본,30례정상방광조직표본:종류표본중비기층침윤성암104례,기층침윤성암44례;G147례、G2 73례、G3 28례;단발종류89례,다발종류59례;비기층침윤성암중미복발40례,복발64례.채용LSAB면역조직화학방법,검측방광암화정상조직중CXCR7단백적표체,병결합림상자료진행분석. 결과정상조직중CXCR7단백적표체수평위10.0%(3/30),종류조직위85.1%(126/148);단발급다발종류CXCR7단백고표체솔분별위49.4%(44/89)화71.2%(42/59),G1、G2、G3방광암CXCR7단백고표체양성솔분별위34.0%(16/47)、65.8%(48/73)、78.6%(22/28),차이균유통계학의의(P＜0.01).비기층침윤성종류화기층침윤성종류중CXCR7단백고표체양성솔위51.9%화72.7%,조간차이유통계학의의(P＜0.05).비기층침윤성방광암중,복발조여미복발조중CXCR7단백고표체양성솔위64.1%화32.5%,차이유통계학의의(P＜0.01).Kaplan-Merier곡선현시,CXCR7단백고표체조환자화CXCR7단백저표체조환자술후무복발생존솔비교,차이유통계학의의(P＜0.01). 결론CXCR7단백고표체여방광이행세포암적악성정도급예후상관,제시CXCR7여방광암적발생발전존재상관성.
Objective To explore the expression of CXCR7 in bladder cancer and analyze its clinical significance and relationship with bladder cancer recurrence. Methods The expressions of CXCR7 protein in 148 specimens of bladder cancer and 30 specimens of normal bladder tissues were detected by immunohistochemical staining and its clinical significance was then analyzed. Results The expression of CXCR7 protein was higher in bladder cancers than in the adjacent normal tissues (P＜0.01). CXCR7 protein expression rates were 49. 4% and 71.2% in mutifocal tumors and unifocal tumors, while 34.0%, 65.8% and 78. 6% in G1, G2, and G3 tumors, respectively (P＜0. 01). Expression of CXCR7 protein was higher in muscle invasive bladder cancers than in non-muscle invasive bladder cancers (72. 7% versus 51.9% ,P＜0.05). In patients followed up for 2-95 months, CXCR7 protein expression was significantly higher in patients with recurrence than with non-recurrence (64. 1% versus 32.5%, P＜0.01). Kaplan-Meier analysis and the log-rark test showed that the recurrence-free survival was significantly different between the group of lower CXCR7 expression group and the higher expression group (P＜0.01). Conclusions The expression of CXCR7 protein is high in bladder cancer and the analysis of CXCR7 protein expression is potentially valuable in prognostic evaluation of bladder cancers. CXCR7 may play a role in the development of bladder urothelial cell cancer.