中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2010年
12期
1231-1233
,共3页
王晓勤%刘存杰%郑菊阳%樊东升
王曉勤%劉存傑%鄭菊暘%樊東升
왕효근%류존걸%정국양%번동승
脑梗死%半胱氨酸蛋白酶抑制剂C%肌酐
腦梗死%半胱氨痠蛋白酶抑製劑C%肌酐
뇌경사%반광안산단백매억제제C%기항
Cerebral infarction%Cystatin C%Creatinine
目的 探讨血清半胱氨酸蛋白酶抑制剂C浓度、血清肌酐浓度对脑梗死发病的影响.方法 选择经临床、颅脑CT和(或)MRI确诊的脑梗死患者84例及同期体检正常者76例,酶联免疫法测定血清半胱氨酸蛋白酶抑制剂C浓度,苦味酸法测定肌酐浓度,观察血清半胱氨酸蛋白酶抑制剂C、肌酐与脑梗死发病的关系.结果 脑梗死组血清半胱氨酸蛋白酶抑制剂C的浓度[(1.69±0.60)mg/L]明显低于对照组[(2.00±0.67)mg/L],血清肌酐的浓度[(86.62±14.02)μmol/L]明显高于对照组[(80.88±13.71)μmol/L],比较差异均有统计学意义(P<0.05).相关分析显示血清半胱氨酸蛋白酶抑制剂C与脑梗死呈负相关(r=-0.238,P=0.002),血清肌酐与脑梗死呈正相关(r=0.208,P=0.010).结论 血清半胱氨酸蛋白酶抑制剂C、肌酐与脑梗死发病相关,半胱氨酸蛋白酶抑制剂C可能是脑梗死发病的一种保护因素,而肌酐可能是脑梗死发病的一种危险因素.
目的 探討血清半胱氨痠蛋白酶抑製劑C濃度、血清肌酐濃度對腦梗死髮病的影響.方法 選擇經臨床、顱腦CT和(或)MRI確診的腦梗死患者84例及同期體檢正常者76例,酶聯免疫法測定血清半胱氨痠蛋白酶抑製劑C濃度,苦味痠法測定肌酐濃度,觀察血清半胱氨痠蛋白酶抑製劑C、肌酐與腦梗死髮病的關繫.結果 腦梗死組血清半胱氨痠蛋白酶抑製劑C的濃度[(1.69±0.60)mg/L]明顯低于對照組[(2.00±0.67)mg/L],血清肌酐的濃度[(86.62±14.02)μmol/L]明顯高于對照組[(80.88±13.71)μmol/L],比較差異均有統計學意義(P<0.05).相關分析顯示血清半胱氨痠蛋白酶抑製劑C與腦梗死呈負相關(r=-0.238,P=0.002),血清肌酐與腦梗死呈正相關(r=0.208,P=0.010).結論 血清半胱氨痠蛋白酶抑製劑C、肌酐與腦梗死髮病相關,半胱氨痠蛋白酶抑製劑C可能是腦梗死髮病的一種保護因素,而肌酐可能是腦梗死髮病的一種危險因素.
목적 탐토혈청반광안산단백매억제제C농도、혈청기항농도대뇌경사발병적영향.방법 선택경림상、로뇌CT화(혹)MRI학진적뇌경사환자84례급동기체검정상자76례,매련면역법측정혈청반광안산단백매억제제C농도,고미산법측정기항농도,관찰혈청반광안산단백매억제제C、기항여뇌경사발병적관계.결과 뇌경사조혈청반광안산단백매억제제C적농도[(1.69±0.60)mg/L]명현저우대조조[(2.00±0.67)mg/L],혈청기항적농도[(86.62±14.02)μmol/L]명현고우대조조[(80.88±13.71)μmol/L],비교차이균유통계학의의(P<0.05).상관분석현시혈청반광안산단백매억제제C여뇌경사정부상관(r=-0.238,P=0.002),혈청기항여뇌경사정정상관(r=0.208,P=0.010).결론 혈청반광안산단백매억제제C、기항여뇌경사발병상관,반광안산단백매억제제C가능시뇌경사발병적일충보호인소,이기항가능시뇌경사발병적일충위험인소.
Objective To investigate the correlation of serum cystatin C and creatinine levels with cerebral infarction. Methods Eighty-four patients with cerebral infarction diagnosed by clinical manifestations, CT and (or) MRI and 76 healthy subjects were selected. Cystatin C level was tested by enzyme-linked immunosorbent assay (ELISA) and creatinine level was tested by the method of nitroxanthic acid. The correlation of cystatin C and creatinine levels with cerebral infarction was explored. Results The level of serum cystatin C in the cerebral infarction group (1.69±0.60 mg/L) was significantly lower as compared with that in the control group (2.00±0.67 mg/L) (t=-3.084, P=0.002); the level of serum creatinine in the cerebral infarction group (86.62±14.02 μmol/L) was significantly higher as compared with that in the control group (80.88±13.71 μmol/L) (t=2.611, P=0.010). Negative correlation between level of serum cystain C and cerebral infarction was noted (r=-0.238, P=0.002),while the level of serum creatinine was positively related to cerebral infarction (r=0.208, P=0.010).Conclusion A close correlation between cerebral infarction and both the levels of cystain C and creatinine exists, with cystatin C being a protective factor and creatinine being a risk factor for clinical cerebral infarction.