中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
7期
28-29
,共2页
肺癌%血清%肿瘤标记物%联合检测
肺癌%血清%腫瘤標記物%聯閤檢測
폐암%혈청%종류표기물%연합검측
Lung cancer%Serum%Tumor makers%Combined detection
目的 探讨血清肿瘤标志物细胞角蛋白21-1(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、鳞癌相关抗原(SCCAg)联合检测对肺癌诊断的临床应用价值.方法 采用电化学发光法检测203例肺癌患者(肺癌组)、100例肺部良性病变患者(良性对照组)和50例健康体检者(正常对照组)血清中的四种肿瘤标志物,并用统计学方法比对分析.结果 肺癌患者组血清四种肿瘤标志物水平明显高于良性对照组和正常对照组(P<0.01),CYFRA21-1敏感性为70.9%,特异性为94.0%;NSE敏感性为36.5%,特异性为 92.0%;CEA敏感性为46.8%,特异性为90.0%;SCCAg敏感性为46.3%,特异性为95.0%;四项联合检测可大大提高肺癌诊断的敏感性,敏感性高达95.1%,特异性为82.0%.结论 联合检测血清中的CYFRA21-1、NSE、CEA、SCCAg可有效提高肺癌诊断的敏感性,对肺癌的早期诊断有重要临床应用价值.
目的 探討血清腫瘤標誌物細胞角蛋白21-1(CYFRA21-1)、神經元特異性烯醇化酶(NSE)、癌胚抗原(CEA)、鱗癌相關抗原(SCCAg)聯閤檢測對肺癌診斷的臨床應用價值.方法 採用電化學髮光法檢測203例肺癌患者(肺癌組)、100例肺部良性病變患者(良性對照組)和50例健康體檢者(正常對照組)血清中的四種腫瘤標誌物,併用統計學方法比對分析.結果 肺癌患者組血清四種腫瘤標誌物水平明顯高于良性對照組和正常對照組(P<0.01),CYFRA21-1敏感性為70.9%,特異性為94.0%;NSE敏感性為36.5%,特異性為 92.0%;CEA敏感性為46.8%,特異性為90.0%;SCCAg敏感性為46.3%,特異性為95.0%;四項聯閤檢測可大大提高肺癌診斷的敏感性,敏感性高達95.1%,特異性為82.0%.結論 聯閤檢測血清中的CYFRA21-1、NSE、CEA、SCCAg可有效提高肺癌診斷的敏感性,對肺癌的早期診斷有重要臨床應用價值.
목적 탐토혈청종류표지물세포각단백21-1(CYFRA21-1)、신경원특이성희순화매(NSE)、암배항원(CEA)、린암상관항원(SCCAg)연합검측대폐암진단적림상응용개치.방법 채용전화학발광법검측203례폐암환자(폐암조)、100례폐부량성병변환자(량성대조조)화50례건강체검자(정상대조조)혈청중적사충종류표지물,병용통계학방법비대분석.결과 폐암환자조혈청사충종류표지물수평명현고우량성대조조화정상대조조(P<0.01),CYFRA21-1민감성위70.9%,특이성위94.0%;NSE민감성위36.5%,특이성위 92.0%;CEA민감성위46.8%,특이성위90.0%;SCCAg민감성위46.3%,특이성위95.0%;사항연합검측가대대제고폐암진단적민감성,민감성고체95.1%,특이성위82.0%.결론 연합검측혈청중적CYFRA21-1、NSE、CEA、SCCAg가유효제고폐암진단적민감성,대폐암적조기진단유중요림상응용개치.
Objective To investigate the clinical value of combined detection of serum tumor makers CYFRA21-1, NSE, CEA and SCCAg in diagnosis of lung cancer. Methods To detect serum tumor markers of 203 patients with lung cancer (lung cancer group), 100 patients with benign lesions(benign control group)and 50 cases of physical examination persons (normal control group) with electrochemical luminescence method, it was statistical analyzed retrospectively.Results The four kinds of serum tumor makers in lung cancer group were obviously higher than bengin control group and normal control group (P<0.01). The sensitivity of CYFRA21-1 was 70.9%, specificity was 94.0%.The sensitivity of NSE was 36.5%, specificity was 92.0%.The sensitivity of CEA was 46.8%, specificity was 90.0%. The sensitivity of SCCAg was 46.3%, specificity was 95.0%. The sensitivity of combined detection was higher than any of them, the sensitivity of the four combined detections was 95.1%, specificity was 82.0%. Conclusions Combined detection of serum markers may effectively improve the sensitivity of lung cancer diagnosis and it has important value of clinical applications for early diagnosis of lung cancer.
