CAJ | 학술논문

T细胞和B细胞介导的免疫应答在自身免疫损伤性疾病的发生与调控中起着至关重要的作用.NF-kappa B Activator 1(Act1)是近年来新发现的NF-κB活化因子,参与IL-17、IL-25信号传导的正向调节与CD40L、BAFF信号通路的负向调节,与Th17细胞和B细胞介导的免疫损伤性疾病以及肿瘤的发生发展有着密切的关系.Act1在IL-17信号和CD40L-BAFF通路中如此截然相反的作用可能归因于其不同的结构域.Act1这种精巧的调节机制也许有助于机体对病原体的防御与自身耐受平衡的调节.
T세포화B세포개도적면역응답재자신면역손상성질병적발생여조공중기착지관중요적작용.NF-kappa B Activator 1(Act1)시근년래신발현적NF-κB활화인자,삼여IL-17、IL-25신호전도적정향조절여CD40L、BAFF신호통로적부향조절,여Th17세포화B세포개도적면역손상성질병이급종류적발생발전유착밀절적관계.Act1재IL-17신호화CD40L-BAFF통로중여차절연상반적작용가능귀인우기불동적결구역.Act1저충정교적조절궤제야허유조우궤체대병원체적방어여자신내수평형적조절.
T and B cell-mediated immune responses play a critical role in the control and modulation of autoimmune diseases. NF-kappa B Activator 1 (Act1) , also called (connection to Iκ B kinase and stress-activated protein kinases,CIKS), is a recently identified molecule, which activates NF-κB . Recent studies have shown that Act1 is a key positive regulator of IL-17 signaling pathway ,and an important negative regulator of B cell-mediated humeral immune responses through its function in CD40L and BAFF signaling. Act1 is critical for TH17 and B cell mediated autoimmune and inflammatory responses. Moreover, Actl may play important roles in ontogenesis. Such seemingly opposite functions of Act1 in CD40-BAFFR and IL-17R signaling are orchestrated by different domains in Act1. Such delicate regulatory mechanisms may provide a common vehicle to promote balance between host defense to pathogens and tolerance to self.