国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
6期
789-792
,共4页
功能失调性子宫出血%左炔诺孕酮
功能失調性子宮齣血%左炔諾孕酮
공능실조성자궁출혈%좌결낙잉동
Dysfunctional uterine bleeding%Levonorgestrel
目的 探讨左炔诺孕酮(商品名:毓婷)治疗功能失调性子宫出血的临床疗效.方法 选择2009年1月-2011年1月期间我院妇科门诊诊断为围绝经期无排卵性功血患者56例,用炔诺酮(妇康片)口服治疗效果不理想者36例,改用毓婷口服治疗3个月经周期.观察止血时间,停药后1个月、3个月随访观察月经量、月经周期变化；并对用药前后Hb、ALT、AST、BUN、CRE进行监测.结果 毓婷口服6小时内迅速止血率为69.44％,24～48小时内止血率为30.56％,停药后1个月治疗有效率为91.66％,3个月有效率为72.22％,用药前与用药3个月后Hb、ALT、AST、BUN、CRE结果比较,Hb明显上升,用药前后存在统计学差异(P＜0.05); ALT、AST、BUN、CRE无统计学差异(P＞0.05).结论 毓婷治疗功血近期效果较好,止血效果明显,用药期间副作用少,远期效果尚需进一步观察.
目的 探討左炔諾孕酮(商品名:毓婷)治療功能失調性子宮齣血的臨床療效.方法 選擇2009年1月-2011年1月期間我院婦科門診診斷為圍絕經期無排卵性功血患者56例,用炔諾酮(婦康片)口服治療效果不理想者36例,改用毓婷口服治療3箇月經週期.觀察止血時間,停藥後1箇月、3箇月隨訪觀察月經量、月經週期變化；併對用藥前後Hb、ALT、AST、BUN、CRE進行鑑測.結果 毓婷口服6小時內迅速止血率為69.44％,24～48小時內止血率為30.56％,停藥後1箇月治療有效率為91.66％,3箇月有效率為72.22％,用藥前與用藥3箇月後Hb、ALT、AST、BUN、CRE結果比較,Hb明顯上升,用藥前後存在統計學差異(P＜0.05); ALT、AST、BUN、CRE無統計學差異(P＞0.05).結論 毓婷治療功血近期效果較好,止血效果明顯,用藥期間副作用少,遠期效果尚需進一步觀察.
목적 탐토좌결낙잉동(상품명:육정)치료공능실조성자궁출혈적림상료효.방법 선택2009년1월-2011년1월기간아원부과문진진단위위절경기무배란성공혈환자56례,용결낙동(부강편)구복치료효과불이상자36례,개용육정구복치료3개월경주기.관찰지혈시간,정약후1개월、3개월수방관찰월경량、월경주기변화；병대용약전후Hb、ALT、AST、BUN、CRE진행감측.결과 육정구복6소시내신속지혈솔위69.44％,24～48소시내지혈솔위30.56％,정약후1개월치료유효솔위91.66％,3개월유효솔위72.22％,용약전여용약3개월후Hb、ALT、AST、BUN、CRE결과비교,Hb명현상승,용약전후존재통계학차이(P＜0.05); ALT、AST、BUN、CRE무통계학차이(P＞0.05).결론 육정치료공혈근기효과교호,지혈효과명현,용약기간부작용소,원기효과상수진일보관찰.
Objective To study the clinical efficacy of levonorgestrel (brand name:Yu Ting) in treatment for dysfunctional uterine bleeding (DUB).Methods 56 cases diagnosed as peri-menopausal patients with anovulatory DUB by gynecology outpatient department in our hospital from January 2009 to January 2011 were treated with oral administration of norethisterone,but no good effect was found in 36 cases, then changed to take levonorgestrel for 3 menstrual cycles.The bleeding time,1 month after treatment,3 months follow-up observation of menstrual flow,menstrual cycle changes were observed,and the levels of Hb,ALT,AST,BUN and CRE before and after treatment were also monitored.Results The rapid hemostatic rate of Yu Ting orally taking for 6 hours was 69.44％,hemostatic rate during 24 ～ 48 hours was 30.56％.The effective rate 1 month after treatment was 91.66％,the one of 3 months was 72.22％,there was a significant difference among them (P＜ 0.05); 3 months before and after treatment,the levels of Hb,ALT,AST,BUN and CRE were compared,Hb level significantly increased after treatment,with a significant difference (P＜ 0.05); there was no significant changes in levels of ALT,AST,BUN and CRE (P ＞ 0.05).Conclusion Levonorgestrel has good effects in treatment for dysfunctional uterine bleeding,obvious results in hemostasis,a low incidence rate of side effects during treatment,but longterm effects need further observation.
