CAJ | 학술논문

X染色体连锁的凋亡抑制蛋白(XIAP)是凋亡抑制蛋白(IAP)家族中的重要一员,XIAP通过抑制半胱天冬酶途径及参与其他细胞凋亡途径抑制细胞的凋亡,在肿瘤的发生的过程中起者重要作用.近年来,以此为靶点,通过下调XIAP的表达,达到肿瘤治疗目的研究成为新的研究热点,同时以Ⅺ-AP作为肿瘤的恶性度指标及预后指标的可行性正在探讨中.
X염색체련쇄적조망억제단백(XIAP)시조망억제단백(IAP)가족중적중요일원,XIAP통과억제반광천동매도경급삼여기타세포조망도경억제세포적조망,재종류적발생적과정중기자중요작용.근년래,이차위파점,통과하조XIAP적표체,체도종류치료목적연구성위신적연구열점,동시이Ⅺ-AP작위종류적악성도지표급예후지표적가행성정재탐토중.
XIAP(X-linked inhibitor of apoptosis protein)is one of the most important members of IAPs family.It inhibits cell apoptosis mainly by inhibiting the caspases activation and interfering with other apoptotic pathway,which plays a critical role in tumor development.Recently,genetic therapy targeting on XIAP for malignant tumors has deeply developed.Research on XIAP as a malignant and prognositic indicator is ongoing.