CAJ | 학술논문

目的探讨临床T1、T2、 N0、M0.乳腺癌腋窝淋巴结转移状况及临床意义.方法结合原发肿瘤位置、年龄、病理等,分析了276例临床T1、T2 N0M0乳腺癌患者腋窝淋巴结转移情况及意义.结果临床T1 N0M0.腋淋巴结转移率低于T2 N0M0乳腺癌患者(P=0.027),乳腺中央区与外下象限乳腺癌发生腋淋巴结转移明显高于其他部位肿瘤(P=0.004);乳腺外侧象限肿瘤腋窝下组淋巴结转移率高于其他部位肿瘤组(P=0.000);乳头中央区和内侧象限乳腺癌腋上组淋巴结转移高于乳腺外侧象限肿瘤(P=0.000).非特殊型癌发生淋巴结转移明显高于早期癌和其他类型(P-0.001).9例单纯癌6例发生2组以上腋淋巴结转移.90例发生腋淋巴结转移的病例中,>50岁者62例(68.9%)发生腋淋巴结转移,≤50岁者28例(31.1%)发生腋淋巴结转移(P=0·000).发现"跳跃式"转移病例2例(0.7%),均为临床T2 N0M0患者,肿瘤位于乳头中央区1例,外下象限者1例.其中浸润型导管癌1例,单纯癌1例.结论研究临床T1、T2 N0M0乳腺癌腋窝转移淋巴结分布情况对开展SLNB及制定合理的治疗方案有一定指导价值.
목적 탐토림상T1、T2、 N0、M0.유선암액와림파결전이상황급림상의의.방법 결합원발종류위치、년령、병리등,분석료276례림상T1、T2 N0M0유선암환자액와림파결전이정황급의의.결과 림상T1 N0M0.액림파결전이솔저우T2 N0M0유선암환자(P=0.027),유선중앙구여외하상한유선암발생액림파결전이명현고우기타부위종류(P=0.004);유선외측상한종류액와하조림파결전이솔고우기타부위종류조(P=0.000);유두중앙구화내측상한유선암액상조림파결전이고우유선외측상한종류(P=0.000).비특수형암발생림파결전이명현고우조기암화기타류형(P-0.001).9례단순암6례발생2조이상액림파결전이.90례발생액림파결전이적병례중,>50세자62례(68.9%)발생액림파결전이,≤50세자28례(31.1%)발생액림파결전이(P=0·000).발현"도약식"전이병례2례(0.7%),균위림상T2 N0M0환자,종류위우유두중앙구1례,외하상한자1례.기중침윤형도관암1례,단순암1례.결론 연구림상T1、T2 N0M0유선암액와전이림파결분포정황대개전SLNB급제정합리적치료방안유일정지도개치.
Objective To study the metastasis of lymph node of breast cancer patients in clinical T1-T2 N0 M0 and its clinical significance in (sentinel lymph node biopsy, SLNB). Methods A total of 276 pa-tients of breast cancer were enrolled in the study (T1 N0M0 cases =115 ; T2N0M0 cases = 161 ). The metas-tasis and distribution of axillary node by virtue of the location of primary tumor, ages and pathologic status were analyzed. Results The metastasis rate of axillary node in T1 N0M0 patients was less than T2 N0 M0 (P =0.027), while that in the central and lower outer quadrant's was higher than in other' s parts(P =0.004).When the tumor located in outer quadrant, the axillary node metastasis rate of Berg I was highest in the cen-tral, outer and inner quadrant(P =0.000). But the metastasis rate of Berg Ⅲ was lowest in the three quad-rants (P = 0. 000). For the pathologic status, the metastasis rate of invasive carcinoma-not otherwise speci-fied(NOS) was higher than early breast carcinoma and other pathologic categories (P =0.000). More than 2 groups axillary node metastasis was found in 6 of 9 patients with carcinoma simplex. The 90 cases with axilla-ry node metastasis were analyzed by age. Axillary node was easier for metastasis in those cases aged above 50years than those below 50 years(68.9% vs 31.1% )(P =0. 000). Two eases with skip metastasis were in T2 No Mo (invasive ductal carcinoma disease = 1, carcinoma simplex disease = 1 ). Conclusion The distri-bution of the metastasis of lymph node in clinical T1 ,T2 N0M0 breast cancer plays an important role in SLNB and formulating reasonable treatment protocols.