CAJ | 학술논문

胰岛素是体内唯一降低血糖的激素,目前,临床上主要使用胰岛素治疗糖尿病.然而,胰岛素不仅是一个重要的代谢调节激素,而且是一个重要的抗炎因子.其发挥抗炎作用的具体机制可能为:直接调节炎性反应因子,抑制氧化应激,调节一氧化氮的表达,在血管水平发挥抗炎作用,促进辅助性T细胞(Th)-2的转化,抑制白细胞介素-6-信号转导与转录激活因子(IL-6-STAT)炎性反应通路,降低C反应蛋白水平,下调Toll样受体等.
이도소시체내유일강저혈당적격소,목전,림상상주요사용이도소치료당뇨병.연이,이도소불부시일개중요적대사조절격소,이차시일개중요적항염인자.기발휘항염작용적구체궤제가능위:직접조절염성반응인자,억제양화응격,조절일양화담적표체,재혈관수평발휘항염작용,촉진보조성T세포(Th)-2적전화,억제백세포개소-6-신호전도여전록격활인자(IL-6-STAT)염성반응통로,강저C반응단백수평,하조Toll양수체등.
Insulin is the only hormone that can reduce blood glucose and mainly used to treat diabetes clinically.However,insulin can exert beneficial effects of anti-inflammation in addition to its important role in metabolic regulation.Mechanisms of anti-inflammation include regulating proinflammatory cytokines directly,inhibiting oxidative stress,regulating the expression of active nitric oxide ( NO),exerting anti-inflammatory effects in blood vessel,promoting a shift toward a Th2-type response,inhibiting the interleukin (IL)-6 -signal transducer and activators of transcription(STAT) signal transduction,reducing C-reactive proteins and down-regulating Toll-like receptors,etc.