CAJ | 학술논문

目的探讨嗅觉功能检测对阿尔茨海默病(AD)的早期诊断价值.方法用图片介导的气味识别试验分别检测21例AD患者(AD组)及21例健康体检者(对照组)的嗅觉察觉阈、嗅觉识别阈,并分析其与简易智能状态检查(MMSE)之间的相关性.结果 AD组患者有不同程度的嗅觉障碍,嗅觉察觉阈(1.81±0.75)分,嗅觉识别阈(2.48±0.68)分,均高于对照组的(1.24±0.89)分和(2.00±0.71)分.差异有统计学意义(P<0.05).AD组MMSE评分与嗅觉察觉阈、嗅觉识别阈呈负相关r=-0.50、-0.54,P<0.01).结论嗅觉功能检测可帮助诊断早期AD,单独采用此方法存在一定的局限性,应与其他方法联合诊断早期AD.
목적 탐토후각공능검측대아이자해묵병(AD)적조기진단개치.방법 용도편개도적기미식별시험분별검측21례AD환자(AD조)급21례건강체검자(대조조)적후각찰각역、후각식별역,병분석기여간역지능상태검사(MMSE)지간적상관성.결과 AD조환자유불동정도적후각장애,후각찰각역(1.81±0.75)분,후각식별역(2.48±0.68)분,균고우대조조적(1.24±0.89)분화(2.00±0.71)분.차이유통계학의의(P<0.05).AD조MMSE평분여후각찰각역、후각식별역정부상관r=-0.50、-0.54,P<0.01).결론 후각공능검측가방조진단조기AD,단독채용차방법존재일정적국한성,응여기타방법연합진단조기AD.
Objective To study the early diagnostic value of olfactory function measurement to Alzheimer disease (AD). Method Detected the thresholds of detectability, identification threshold with pictu.re-based odor identification test in 21 AD patients (AD group) and 21 healthy elderly people (control group), and evaluated the relationship with mini-mental state examination (MMSE). Results AD group was impaired on threshglds of detectability [(1.81±0.75) scores], identification threshold [(2.48±0.68) scores]compared with control group [(1.24±0.89) scores and (2.00±0.71) scores, P< 0.05]. The thres holds of detectability and identification threshold were related to MMSE in AD group (r =-0.50,-0.54, P< 0.01). Conclusion The early diagnostic value of olfactory function measurement to AD is very great.