中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2012年
5期
322-328
,共7页
支原体感染%关节炎,类风湿%Meta分析%相关性
支原體感染%關節炎,類風濕%Meta分析%相關性
지원체감염%관절염,류풍습%Meta분석%상관성
Mycoplasma infections%Arthritis,rheumatoid%Meta-analysis%Association
目的 探讨支原体感染与类风湿关节炎(RA)的相关性.方法 通过文献检索,根据选择标准收集病例对照研究文献,对文献进行质量评价,运用荟萃分析(Meta分析)方法进行综合定量分析,计算合并比值比(OR)及其95％的可信区间(95％CI).结果 有17篇文献入选,共纳入729例RA患者和1191例对照.Meta分析显示RA与支原体感染存在相关性,其中RA与非RA组的支原体感染率差异有统计学意义[ OR =4.40,95％CI(2.26～8.56),P＜0.01],按照检测方法和发表时间不同进行敏感性分析,显示结果差异无统计学意义.RA与骨关节炎比较[OR=11.29,95％CI(5.55～22.97),P＜0.01],RA与健康对照组比较,差异有统计学意义[ OR=6.80,95％CI( 3.96～11.67),P＜0.01]；RA与反应性关节炎(ReA)比较,差异无统计学意义[ OR=1.02,95％CI(0.51～2.06),P=0.95],RA与痛风性关节炎(GA)比较,差异无统计学意义[OR=3.38,95％CI(0.80～14.19),P=0.10],尚不能认为支原体在RA与ReA组、RA与GA组的感染率存在差异.结论 ①Meta分析显示,RA与支原体感染有关；②支原体在RA中的地位是否等同于在ReA中的地位,需要大样本的临床研究及基础研究；③RA与GA组支原体感染率的比较由于GA组病例数少,尚需要大样本的科学研究进一步证实.
目的 探討支原體感染與類風濕關節炎(RA)的相關性.方法 通過文獻檢索,根據選擇標準收集病例對照研究文獻,對文獻進行質量評價,運用薈萃分析(Meta分析)方法進行綜閤定量分析,計算閤併比值比(OR)及其95％的可信區間(95％CI).結果 有17篇文獻入選,共納入729例RA患者和1191例對照.Meta分析顯示RA與支原體感染存在相關性,其中RA與非RA組的支原體感染率差異有統計學意義[ OR =4.40,95％CI(2.26～8.56),P＜0.01],按照檢測方法和髮錶時間不同進行敏感性分析,顯示結果差異無統計學意義.RA與骨關節炎比較[OR=11.29,95％CI(5.55～22.97),P＜0.01],RA與健康對照組比較,差異有統計學意義[ OR=6.80,95％CI( 3.96～11.67),P＜0.01]；RA與反應性關節炎(ReA)比較,差異無統計學意義[ OR=1.02,95％CI(0.51～2.06),P=0.95],RA與痛風性關節炎(GA)比較,差異無統計學意義[OR=3.38,95％CI(0.80～14.19),P=0.10],尚不能認為支原體在RA與ReA組、RA與GA組的感染率存在差異.結論 ①Meta分析顯示,RA與支原體感染有關；②支原體在RA中的地位是否等同于在ReA中的地位,需要大樣本的臨床研究及基礎研究；③RA與GA組支原體感染率的比較由于GA組病例數少,尚需要大樣本的科學研究進一步證實.
목적 탐토지원체감염여류풍습관절염(RA)적상관성.방법 통과문헌검색,근거선택표준수집병례대조연구문헌,대문헌진행질량평개,운용회췌분석(Meta분석)방법진행종합정량분석,계산합병비치비(OR)급기95％적가신구간(95％CI).결과 유17편문헌입선,공납입729례RA환자화1191례대조.Meta분석현시RA여지원체감염존재상관성,기중RA여비RA조적지원체감염솔차이유통계학의의[ OR =4.40,95％CI(2.26～8.56),P＜0.01],안조검측방법화발표시간불동진행민감성분석,현시결과차이무통계학의의.RA여골관절염비교[OR=11.29,95％CI(5.55～22.97),P＜0.01],RA여건강대조조비교,차이유통계학의의[ OR=6.80,95％CI( 3.96～11.67),P＜0.01]；RA여반응성관절염(ReA)비교,차이무통계학의의[ OR=1.02,95％CI(0.51～2.06),P=0.95],RA여통풍성관절염(GA)비교,차이무통계학의의[OR=3.38,95％CI(0.80～14.19),P=0.10],상불능인위지원체재RA여ReA조、RA여GA조적감염솔존재차이.결론 ①Meta분석현시,RA여지원체감염유관；②지원체재RA중적지위시부등동우재ReA중적지위,수요대양본적림상연구급기출연구；③RA여GA조지원체감염솔적비교유우GA조병례수소,상수요대양본적과학연구진일보증실.
Objective To systematically review the relationship between mycoplasma infection and rheumatoid arthritis (RA).Methods Articles on case-control studies about the relation between mycoplasma infection and RA were collected by literature searching according to the selection criteria.Meta-analyses were performed for the included studies using RevMan 4.3.2 software.The odds ratio (OR) and its corresponding 95％ confidence interval (95％CI) were calculated by Meta-analysis.Results Seventeen casecontrol studies involving 729 RA patients and 1191non-RA controls,such as osteoarthritis (OA),reactive arthritis (ReA),gouty arthritis (GA),healthy controls were included.The results of Meta-analyses showed that there was a significant difference in the infection ratio of mycoplasma between patients with RA and non-RA (OR=4.40,95％CI 2.26 to 8.56,P＜0.01),and sensitivity analysis according to different published date and detection methods showed no difference.There were also significant differences between RA patients and OA patients (OR=11.29,95％CI 5.55 to 22.97,P＜0.01) and healthy controls (OR=6.80,95％CI 3.96 to 11.67,P＜0.01).Conclusion Mycoplasma infection is associated with RA.More evidence are needed to prove whether mycoplasma has played an equal role in RA and ReA,as well as the significant difference of mycoplasma infection between RA and GA groups.
