中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2011年
1期
86-88
,共3页
冠心病%抗氧化治疗%血红素氧化酶-1
冠心病%抗氧化治療%血紅素氧化酶-1
관심병%항양화치료%혈홍소양화매-1
Coronary artery disease%Antioxidant treatment%Heme Oxidase-1
目的 观察冠心病患者使用他汀类药物、血管紧张素转化酶抑制剂和血管紧张素受体拮抗剂等抗氧化剂治疗对血红素氧化酶-1表达水平的影响.方法 使用Western blot方法检测经冠状动脉造影确诊的60例冠心病患者抗氧化治疗后3个月外周血白细胞血红素氧化酶-1表达含量的变化.结果 治疗前血红素氧化酶-1表达水平是112.7±6.3(蛋白带灰度峰值),抗氧化治疗后表达水平增至168.9±6.8,差异有统计学意义(t=2.432,P=0.008).结论 他汀类药物、血管紧张素转化酶抑制剂和血管紧张素受体拮抗剂对冠心病的治疗作用可能是通过促进血红素氧化酶-1表达实现的.
目的 觀察冠心病患者使用他汀類藥物、血管緊張素轉化酶抑製劑和血管緊張素受體拮抗劑等抗氧化劑治療對血紅素氧化酶-1錶達水平的影響.方法 使用Western blot方法檢測經冠狀動脈造影確診的60例冠心病患者抗氧化治療後3箇月外週血白細胞血紅素氧化酶-1錶達含量的變化.結果 治療前血紅素氧化酶-1錶達水平是112.7±6.3(蛋白帶灰度峰值),抗氧化治療後錶達水平增至168.9±6.8,差異有統計學意義(t=2.432,P=0.008).結論 他汀類藥物、血管緊張素轉化酶抑製劑和血管緊張素受體拮抗劑對冠心病的治療作用可能是通過促進血紅素氧化酶-1錶達實現的.
목적 관찰관심병환자사용타정류약물、혈관긴장소전화매억제제화혈관긴장소수체길항제등항양화제치료대혈홍소양화매-1표체수평적영향.방법 사용Western blot방법검측경관상동맥조영학진적60례관심병환자항양화치료후3개월외주혈백세포혈홍소양화매-1표체함량적변화.결과 치료전혈홍소양화매-1표체수평시112.7±6.3(단백대회도봉치),항양화치료후표체수평증지168.9±6.8,차이유통계학의의(t=2.432,P=0.008).결론 타정류약물、혈관긴장소전화매억제제화혈관긴장소수체길항제대관심병적치료작용가능시통과촉진혈홍소양화매-1표체실현적.
Objective To observe the effects of statins, angiotensin-converting enzyme inhibitor/adrenergic receptor binder ( ACEI/ARB ) treatment on Heme Oxidase-1 ( HO-1 ) expression in patients with coronary artery disease. Methods HO-1 expression in periphery white blood cells was detected using Western blot before and after 3 months treatment of the above antioxidants in 60 patients who were diagnosed as coronary artery disease by coronary angiography. Results HO-1 expression measured by gray scale peak by western blot was significantly higher after 3 months antioxidant treatment than that before antioxidant treatment( 168. 9 t6. 8vs 112.7 ± 6.3, P = 0.008 ). Conclusion Effects of statins and ACEI/ARB in treating coronary artery disease may be due to its promoting expression of HO-1.
