中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2012年
3期
249-255
,共7页
李立明%吕筠%郭彧%Rory Collins%陈君石%Richard Peto%吴凡%陈铮鸣
李立明%呂筠%郭彧%Rory Collins%陳君石%Richard Peto%吳凡%陳錚鳴
리립명%려균%곽욱%Rory Collins%진군석%Richard Peto%오범%진쟁명
慢性病%队列研究%生物样本库
慢性病%隊列研究%生物樣本庫
만성병%대렬연구%생물양본고
Chronic disease%Cohort study%Biobank
目的 探讨环境、个体生活方式、体格和生化指标以及遗传易感性等因素对中国成年人主要慢性病发生、发展的影响.方法 中国慢性病前瞻性研究为一项建立有生物样本库的超大型前瞻性队列研究.2004-2008年在城市和农村各5个地区开展基线调查,包括问卷调查、体格检查和血液样本采集.2008年对随机抽取5％的队列成员进行第一次重复调查.通过常规和定向监测对队列成员进行长期全死因监测和四类主要慢性病的发病监测,并从全民医疗保险数据库获取个体全病种入院诊疗信息.结果 基线调查共入选30～79(平均51.5)岁512 891名对象.其中男性占41.0％,农村人群占55.9％.队列人群男女性现在吸烟率分别为61.3％和2.4％；男性过去一年中每周至少一次饮酒率为33.4％,女性为2.1％；超重肥胖(BMI≥24.0 kg/m2)率,男性为41.8％,女性为45.3％；调查时SBP≥140 mm Hg或DBP≥90 mm Hg(1 mm Hg=1.33 kPa)的比例男性为32.2％,女性为30.2％.不同年龄、性别和地区各主要调查指标均有差异.结论 中国不同地区、年龄、性别及出生年代人群具有不同的慢性病暴露谱.
目的 探討環境、箇體生活方式、體格和生化指標以及遺傳易感性等因素對中國成年人主要慢性病髮生、髮展的影響.方法 中國慢性病前瞻性研究為一項建立有生物樣本庫的超大型前瞻性隊列研究.2004-2008年在城市和農村各5箇地區開展基線調查,包括問捲調查、體格檢查和血液樣本採集.2008年對隨機抽取5％的隊列成員進行第一次重複調查.通過常規和定嚮鑑測對隊列成員進行長期全死因鑑測和四類主要慢性病的髮病鑑測,併從全民醫療保險數據庫穫取箇體全病種入院診療信息.結果 基線調查共入選30～79(平均51.5)歲512 891名對象.其中男性佔41.0％,農村人群佔55.9％.隊列人群男女性現在吸煙率分彆為61.3％和2.4％；男性過去一年中每週至少一次飲酒率為33.4％,女性為2.1％；超重肥胖(BMI≥24.0 kg/m2)率,男性為41.8％,女性為45.3％；調查時SBP≥140 mm Hg或DBP≥90 mm Hg(1 mm Hg=1.33 kPa)的比例男性為32.2％,女性為30.2％.不同年齡、性彆和地區各主要調查指標均有差異.結論 中國不同地區、年齡、性彆及齣生年代人群具有不同的慢性病暴露譜.
목적 탐토배경、개체생활방식、체격화생화지표이급유전역감성등인소대중국성년인주요만성병발생、발전적영향.방법 중국만성병전첨성연구위일항건립유생물양본고적초대형전첨성대렬연구.2004-2008년재성시화농촌각5개지구개전기선조사,포괄문권조사、체격검사화혈액양본채집.2008년대수궤추취5％적대렬성원진행제일차중복조사.통과상규화정향감측대대렬성원진행장기전사인감측화사류주요만성병적발병감측,병종전민의료보험수거고획취개체전병충입원진료신식.결과 기선조사공입선30～79(평균51.5)세512 891명대상.기중남성점41.0％,농촌인군점55.9％.대렬인군남녀성현재흡연솔분별위61.3％화2.4％；남성과거일년중매주지소일차음주솔위33.4％,녀성위2.1％；초중비반(BMI≥24.0 kg/m2)솔,남성위41.8％,녀성위45.3％；조사시SBP≥140 mm Hg혹DBP≥90 mm Hg(1 mm Hg=1.33 kPa)적비례남성위32.2％,녀성위30.2％.불동년령、성별화지구각주요조사지표균유차이.결론 중국불동지구、년령、성별급출생년대인군구유불동적만성병폭로보.
Objective To study the separate and combined effects of environment,lifestyle,physical characteristics,blood biomarkers and genetic factors on aetiology of major chronic diseases in adult Chinese.Methods China Kadoorie Biobank (CKB) is a large blood-based prospective cohort study.The baseline survey took place in 5 urban and 5 rural areas across China during 2004-2008,with collection of data through questionnaire,physical examination and blood samples.Following the baseline survey,5％ of the randomly selected participants were surveyed in 2008,and repeated every 4-5 years.All participants would be followed for cause-specific mortality and morbidity through registries and for any hospital admission through linkages with health insurance databases.Results Overall,512 891 adults aged 30-79 years (mean 51.5) were recruited,including 41.0％ men and 55.9％ from rural areas.Blood collection was successfully done in 99.98％ of the participants.The prevalence of current regular smoking was 61.3％ in men and 2.4％ in women.The prevalence of regular alcohol consumption (i.e.,weekly) was 33.4％ in men and 2.1％ in women.At the baseline,41.8％ of men and 45.3％ of women were overweight or obese (i.e.,BMI≥24.0 kg/m2) and 32.2％ of men and 30.2％ of women were hypertensive (i.e.,SBP≥140 mm Hg or DBP≥90 mm Hg).For each of the main baseline variables,there were large variations on age,sex and areas of study.Conclusion CKB seemed to be a powerful and rich resource in studying the environmental and genetic determinants of major chronic diseases in the Chinese population.
