中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2012年
10期
742-745
,共4页
邬喆斌%曹红%刘婷%吴泽倩%柯伟民%高志良
鄔喆斌%曹紅%劉婷%吳澤倩%柯偉民%高誌良
오철빈%조홍%류정%오택천%가위민%고지량
肝炎,乙型,慢性%肝硬化%肝炎表面抗原,乙型%肝细胞
肝炎,乙型,慢性%肝硬化%肝炎錶麵抗原,乙型%肝細胞
간염,을형,만성%간경화%간염표면항원,을형%간세포
Hepatitis B,chronic%Liver cirrhosis%Hepatitis B surface antigens%Hepatocytes
目的 观察慢性乙型肝炎免疫清除期肝纤维化S1、S2、S3和S4期,相同肝实质细胞体积所分摊HBsAg表达的动态变化. 方法 对89例HBeAg阳性慢性乙型肝炎免疫清除期患者应用电化学发光法检测肝纤维化S1、S2、S3和S4期血清HBsAg的水平；进一步用相同肝实质细胞体积分摊并且两两比较肝纤维化S1、S2、S3和S4期血清HBsAg的水平.使用SPSS 15.0统计软件,组间用两两比较,采用ANOVA检验进行分析. 结果 肝纤维化S1、S2、S3和S4期的血清HBsAg水平分别为(227.2±237.7)IU/ml、(211.0±131.4)IU/ml、(300.2±144.6) IU/ml和(278.7±148.8) IU/ml,四组之间两两比较,差异无统计学意义.用相同肝实质细胞体积进行分摊,在肝纤维化S1、S2、S3和S4期的HBsAg水平分别为(343.9±359.8)IU/ml、(336.4±209.5)IU/ml、(508.7±245.1)IU/ml和(525.2±274.8) IU/ml,四组两两比较,F=3.045,P=0.033,差异有统计学意义,其中,S1与S3、S1 与S4、S2与S3和S2与S4比较,P值分别为0.041、0.046、0.028和0.034,差异均有统计学意义.结论 在慢性乙型肝炎免疫清除期中,随着肝纤维化从S1期向S4期进展,相同肝实质细胞体积所分摊的HBsAg表达逐渐增强.
目的 觀察慢性乙型肝炎免疫清除期肝纖維化S1、S2、S3和S4期,相同肝實質細胞體積所分攤HBsAg錶達的動態變化. 方法 對89例HBeAg暘性慢性乙型肝炎免疫清除期患者應用電化學髮光法檢測肝纖維化S1、S2、S3和S4期血清HBsAg的水平；進一步用相同肝實質細胞體積分攤併且兩兩比較肝纖維化S1、S2、S3和S4期血清HBsAg的水平.使用SPSS 15.0統計軟件,組間用兩兩比較,採用ANOVA檢驗進行分析. 結果 肝纖維化S1、S2、S3和S4期的血清HBsAg水平分彆為(227.2±237.7)IU/ml、(211.0±131.4)IU/ml、(300.2±144.6) IU/ml和(278.7±148.8) IU/ml,四組之間兩兩比較,差異無統計學意義.用相同肝實質細胞體積進行分攤,在肝纖維化S1、S2、S3和S4期的HBsAg水平分彆為(343.9±359.8)IU/ml、(336.4±209.5)IU/ml、(508.7±245.1)IU/ml和(525.2±274.8) IU/ml,四組兩兩比較,F=3.045,P=0.033,差異有統計學意義,其中,S1與S3、S1 與S4、S2與S3和S2與S4比較,P值分彆為0.041、0.046、0.028和0.034,差異均有統計學意義.結論 在慢性乙型肝炎免疫清除期中,隨著肝纖維化從S1期嚮S4期進展,相同肝實質細胞體積所分攤的HBsAg錶達逐漸增彊.
목적 관찰만성을형간염면역청제기간섬유화S1、S2、S3화S4기,상동간실질세포체적소분탄HBsAg표체적동태변화. 방법 대89례HBeAg양성만성을형간염면역청제기환자응용전화학발광법검측간섬유화S1、S2、S3화S4기혈청HBsAg적수평；진일보용상동간실질세포체적분탄병차량량비교간섬유화S1、S2、S3화S4기혈청HBsAg적수평.사용SPSS 15.0통계연건,조간용량량비교,채용ANOVA검험진행분석. 결과 간섬유화S1、S2、S3화S4기적혈청HBsAg수평분별위(227.2±237.7)IU/ml、(211.0±131.4)IU/ml、(300.2±144.6) IU/ml화(278.7±148.8) IU/ml,사조지간량량비교,차이무통계학의의.용상동간실질세포체적진행분탄,재간섬유화S1、S2、S3화S4기적HBsAg수평분별위(343.9±359.8)IU/ml、(336.4±209.5)IU/ml、(508.7±245.1)IU/ml화(525.2±274.8) IU/ml,사조량량비교,F=3.045,P=0.033,차이유통계학의의,기중,S1여S3、S1 여S4、S2여S3화S2여S4비교,P치분별위0.041、0.046、0.028화0.034,차이균유통계학의의.결론 재만성을형간염면역청제기중,수착간섬유화종S1기향S4기진전,상동간실질세포체적소분탄적HBsAg표체축점증강.
Objective The aim of this study was to determine the dynamic expression profile of hepatitis B surface antigen (HBsAg) according to hepatic parenchyma cells' volume at different stages of liver fibrosis during the immune clearance phase.Methods Eighty-nine patients with HBeAg-positive chronic hepatitis B (CHB) in the immune clearance stage were recruited for study.Each patient's serum HBsAg levels were detected by electrochemiluminescence.The serum HBsAg levels were apportioned according to hepatic parenchyma cells' volume at liver fibrosis stages 1,2,3,and 4 and compared by ANOVA.Results The unapportioned serum HBsAg levels (IU/mL) at liver fibrosis stages 1 (227.2 ± 237.7),2 (211.0 ± 131.4),3 (300.1 ± 144.6),and 4 (278.7 ± 148.8) were not significantly different (all comparisons,P range:0.061～0.759).However,when the serum HBsAg levels were apportioned by the same hepatic parenchyma cells' volume at liver fibrosis stages 1 (343.9 ± 359.8),2 (336.4 ± 209.5),3 (508.7 ± 245.1),and 4 (525.2 ± 274.8),the levels were significantly different (all comparisons,F =3.045 and P =0.033; stage 1 vs.3,P =0.041;stage 1 vs.4,P =0.046; stage 2 vs.3,P =0.028; stage 2 vs.4,P =0.034).Conclusion During the immune clearance phase of chronic hepatitis B,increased HBsAg expression is associated with increased hepatic parenchyma cells' volume and progressive liver fibrosis stage.
