CAJ | 학술논문

目的比较单侧、双侧肺减容术后肺气肿家兔动脉血气与肺通气功能的变化.方法 60只家兔随机分为正常对照(A组)、肺气肿(B组)、单侧假手术(C组)、单侧肺减容术(D组)、双侧假手术(E组)和双侧肺减容术(F组).除A组外,其余均采用吸烟加气管内滴注木瓜蛋白酶的方法制作成肺气肿模型.术后8周进行动脉血气分析和肺功能检查.结果与B组比较,D组pH、氧分压(PaO2)和氧饱和度(SaO2)显著升高(P＜0.05),PaCO2显著降低(P＜0.05)；F组pH、PaO2和SaO2显著升高(P ＜0.01),PaCO2显著降低(P＜0.01).与D组比较,F组pH、PaO2和SaO2显著升高(P＜0.05),PaCO2 显著降低(P＜0.05).与B组比较,C组和E组肺功能无显著性差异(P＞0.05)；D组0.5s用力呼气容积( FEV0.5)和FEV0.5/FVC(用力肺活量)显著升高(P＜0.05),功能残气量(FRC )/TLC(肺总容积)、动态顺应性(Cld)和呼气相气道阻力(Re)显著降低(P＜0.05)；F组FEV0.5和FEV0.5/FVC显著升高(P＜0.01),FRC/TLC、Cld和Re显著降低(P＜0.01).与D组比较,F组FEV0.5和FEV0.5/FVC显著升高(P＜0.05),FRC/TLC 、Cld和Re显著降低(P＜0.05).观察期内双侧肺减容术组兔死亡2只,其余各组兔均存活.结论双侧肺减容术较单侧肺减容术更能改善动脉血气和肺通气功能.
목적 비교단측、쌍측폐감용술후폐기종가토동맥혈기여폐통기공능적변화.방법 60지가토수궤분위정상대조(A조)、폐기종(B조)、단측가수술(C조)、단측폐감용술(D조)、쌍측가수술(E조)화쌍측폐감용술(F조).제A조외,기여균채용흡연가기관내적주목과단백매적방법제작성폐기종모형.술후8주진행동맥혈기분석화폐공능검사.결과 여B조비교,D조pH、양분압(PaO2)화양포화도(SaO2)현저승고(P＜0.05),PaCO2현저강저(P＜0.05)；F조pH、PaO2화SaO2현저승고(P ＜0.01),PaCO2현저강저(P＜0.01).여D조비교,F조pH、PaO2화SaO2현저승고(P＜0.05),PaCO2 현저강저(P＜0.05).여B조비교,C조화E조폐공능무현저성차이(P＞0.05)；D조0.5s용력호기용적( FEV0.5)화FEV0.5/FVC(용력폐활량)현저승고(P＜0.05),공능잔기량(FRC )/TLC(폐총용적)、동태순응성(Cld)화호기상기도조력(Re)현저강저(P＜0.05)；F조FEV0.5화FEV0.5/FVC현저승고(P＜0.01),FRC/TLC、Cld화Re현저강저(P＜0.01).여D조비교,F조FEV0.5화FEV0.5/FVC현저승고(P＜0.05),FRC/TLC 、Cld화Re현저강저(P＜0.05).관찰기내쌍측폐감용술조토사망2지,기여각조토균존활.결론 쌍측폐감용술교단측폐감용술경능개선동맥혈기화폐통기공능.
Objective Describes the changes of arterial blood gas analysis and pulmonary functions of emphysematous rabbits after unilateral and bilateral lung volume reduction surgery.Methods Sixty rabbits were randomly and equally divided into 6 groups:control group(A),emphysema group( B),unilateral sham operation group(C),unilateral lung volume reduction surgery group( D),bilateral sham operation group( E ) and bilateral lung volume reduction surgery group(F).Obstructive emphysema was induced with somg and papain in tie rabbits of the remaining groups except the control one.Eight weeks later,arterial blood gas analysis and pulmonary functions were detected.Results Compared with group B,pH,PaO2,PaCO2,SaO2,forced expirratory volume in 0.5 s,froced expiratory capacity,functional residual capacity,total lung capacity,dynamic compliance,and resistance in expiartory phase could be improved in group D ( P ＜ 0.05 ).The amelioration of those results were more obvious in group F ( P ＜0.05).Two rabbits in group F died after opertation.Conclusion Bilateral lung volume reduction surgery could more markedly improve the arterial blood gas analysis and pulmonary functions of emphysematous rabbits than unilateral operation.