CAJ | 학술논문

目的建立稳定可靠的大鼠皮肤撕脱伤模型.方法雄性SD大鼠30只,随机分为轴型皮瓣(9cm×3cm)对照组及牵拉组,任意皮瓣(6cm×4cm)对照组及牵拉组.轴型皮瓣施予牵拉力6kg,任意皮瓣施予牵拉力8kg,牵拉时间分别为8秒和12秒.观察创面收缩及皮瓣坏死情况.结果术后第7天,牵拉组较对照组创面收缩率明显增加(P＜0.05);术后第14天,牵拉组创面收缩率较术后第7天时增加近1倍(P＜0.01),但牵拉8秒组与12秒组间差异无统计学意义.术后第7天,牵拉组皮瓣100%发生部分或大部坏死.轴型皮瓣牵拉8秒导致38%～77%面积坏死,牵拉12秒导致40%～80%面积坏死;任意皮瓣牵拉8秒导致17%～40%面积坏死,牵拉12秒导致24%～43%面积坏死.结论应用大鼠制作皮肤撕脱伤模型是可行的.
목적 건립은정가고적대서피부시탈상모형.방법 웅성SD대서30지,수궤분위축형피판(9cm×3cm)대조조급견랍조,임의피판(6cm×4cm)대조조급견랍조.축형피판시여견랍력6kg,임의피판시여견랍력8kg,견랍시간분별위8초화12초.관찰창면수축급피판배사정황.결과 술후제7천,견랍조교대조조창면수축솔명현증가(P＜0.05);술후제14천,견랍조창면수축솔교술후제7천시증가근1배(P＜0.01),단견랍8초조여12초조간차이무통계학의의.술후제7천,견랍조피판100%발생부분혹대부배사.축형피판견랍8초도치38%～77%면적배사,견랍12초도치40%～80%면적배사;임의피판견랍8초도치17%～40%면적배사,견랍12초도치24%～43%면적배사.결론 응용대서제작피부시탈상모형시가행적.
Objective To create a stable and reliable model of skin avulsion in rats.Methods 30 male,SD rats were randomly divided into axial pattern skin flap(9cm×3cm)group and random pattern skin flap group(6cm×4cm),each having the control groups and avulsion groups.Flaps were subjected to avulsion force of 6 kg in axial pattern skin flaps or 8 kg in random pattern skin flaps,and the lasting time was 8s or 12s,respectively.Retraction of wounds and necrosis of skin flaps were observed.Results There was more significant wound retraction in avulsion groups than that in control groups on post-operation day 7(P＜0.05).The proportion of the wound retraction increased by 1 fold in avulsion groups on post-operation day 14 as compared to post-operation day 7(P＜0.01).Interestingly,necrosis of partial or most of skin flaps was observed in all animals of avulsion groups,while slight necrosis happened in one of six in control animals.The necrosis area of flaps was 38%～77%when avulsed for 8s,and was 40%～80%when avulsed for 12s in axial pattern skin flaps.However,the necrosis area in random pattern skin flaps was smaller than that in axial pattern skin flaps.from 17%～40%when avulsed for 8s to 24%～43%when avulsed for 12s.Conclusions It might be possible to creat animal model of skin avulsion injuries with rats.