CAJ | 학술논문

目的　探讨闽南地区肾小球疾病的临床分型与病理改变之间流行病学意义。方法　全部病例均经皮肾活检。光镜(HE，PASPAM及Masson染色)免疫组化，部分送电镜。结果　原发性肾小球肾炎416例(82.2%)，病理以系膜增生(46.6%)，IgA肾病(22.1%)多见。继发性肾小球肾炎90例中狼疮性肾炎43例(73.3%)，病理以膜增殖为主(52.3%)。结论　系膜性病变仍占肾小球疾病首位，且无明显地区性差异。局灶节段性硬化有逐年增多趋势。狼疮性肾炎发病率低于北京地区。
목적　탐토민남지구신소구질병적림상분형여병리개변지간류행병학의의。방법　전부병례균경피신활검。광경(HE，PASPAM급Masson염색)면역조화，부분송전경。결과　원발성신소구신염416례(82.2%)，병리이계막증생(46.6%)，IgA신병(22.1%)다견。계발성신소구신염90례중랑창성신염43례(73.3%)，병리이막증식위주(52.3%)。결론　계막성병변잉점신소구질병수위，차무명현지구성차이。국조절단성경화유축년증다추세。랑창성신염발병솔저우북경지구。
Objective　To study whether there is epidemiologic significance in clinical classification and the pathological changes of glomerular disease in the south of Fujian. Method　All cases were examined by using percutaneous renal biopsy, light microscopy (staining by HE, PASPAM and Masson), immunohisto chemical staining. Some were examined by electron microscopy. Result　416 cases (82.2%) were primary glomerulonephritis, whose pathology mostly constituted of mesangial proliferative glomerulonephritis (46.6%) and IgA nephropathy (22.1%). 90 cases (17.8%) were secondary glomerulonephritis, 43 cases of which were lupus nephritis, and their pathology was mostly membrahypertrophy (52.3%). Conclusion　Mesangial pathological changes are in the first place of the glomerular diseases and have no regional difference; The incidence of local segmental glomerulosclerosis increases year by year; The incidence of lupus nephritis is lower than that in Beijing region