化学试剂
化學試劑
화학시제
CHEMICAL REAGENTS
2010年
2期
177-180
,共4页
2-芳基苯并呋喃%交叉McMurry反应%氧化环化
2-芳基苯併呋喃%交扠McMurry反應%氧化環化
2-방기분병부남%교차McMurry반응%양화배화
2-arylbenzofurans%cross McMurry coupling reaction%oxidative cyclization reaction
创造了两步合成2-芳基苯并呋喃化合物的新方法.即利用水杨醛或取代水杨醛在低价钛作用下进行交叉McMurry偶联反应,并对交叉偶联产物-邻乙烯基苯酚进行氧化环化获得对应苯并呋喃化合物.此法为脱甲氧基野茉莉醇、野茉莉醇等天然产物的全合成提供了简便有效的方法.
創造瞭兩步閤成2-芳基苯併呋喃化閤物的新方法.即利用水楊醛或取代水楊醛在低價鈦作用下進行交扠McMurry偶聯反應,併對交扠偶聯產物-鄰乙烯基苯酚進行氧化環化穫得對應苯併呋喃化閤物.此法為脫甲氧基野茉莉醇、野茉莉醇等天然產物的全閤成提供瞭簡便有效的方法.
창조료량보합성2-방기분병부남화합물적신방법.즉이용수양철혹취대수양철재저개태작용하진행교차McMurry우련반응,병대교차우련산물-린을희기분분진행양화배화획득대응분병부남화합물.차법위탈갑양기야말리순、야말리순등천연산물적전합성제공료간편유효적방법.
A novel two-steps synthesis of 2-arylbenzofurans has been developed.Firstly,via selective cross McMurry coupling reaction with salicylaldehyde or substituted salicylaldehyde,ortho-vinylphenols was prepared in the presence of low value titanium ion,and then converted into 2-arylbenzofurans by xidative cyclization reaction.It is shown that this method would be efficiently suitable to synthesis demethoxyegonol products.
