CAJ | 학술논문

在肿瘤疫苗中树突状细胞(DC)是启动抗肿瘤免疫的主要辅助细胞.细胞因子信号抑制因子l (SOCS1)对细胞因子信号转导具有抑制作用.最近的研究表明,抑制DC中SOCS1的功能对提高肿瘤疫苗的抗肿瘤活性具有重要作用,并且在如何抑制其功能的方法上也取得了重大进展.
재종류역묘중수돌상세포(DC)시계동항종류면역적주요보조세포.세포인자신호억제인자l (SOCS1)대세포인자신호전도구유억제작용.최근적연구표명,억제DC중SOCS1적공능대제고종류역묘적항종류활성구유중요작용,병차재여하억제기공능적방법상야취득료중대진전.
Dendritic cells (DCs) are the important auxiliary cells in tumor vaccines to activate antitumor immunity.Suppressor of cytokine signaling 1 ( SOCS1 ) has been shown to play an important role in inhibition of cytokine signal transduction.Recent studies show that inhibition of the function of SOCS1 in DCs plays a critical role in strongly enhancing tumor vaccines antitumor activity,and in the methods of restraining SOCS1 's function have also made significant progress.