CAJ | 학술논문

Osteoactivin(OA)是一种最先在骨硬化动物模型中发现的新型糖蛋白.近年来研究表明,OA在骨、肝脏、肾脏等组织中均有不同程度的表达,同时具有多种生物学功能,如成骨细胞分化以及破骨细胞生长、成纤维细胞分化等.OA可诱导成骨细胞及破骨细胞分化,提示其在骨合成代谢方面具有重要作用.但只有少量研究报道了OA作用的可能机制,例如在成纤维细胞中通过细胞外信号调节激酶信号通路,诱导基质金属蛋白酶(MMP)-3的表达以及作为一个下游调节剂,参与调节骨形态发生蛋白(BMP)-2对成骨细胞分化与基质矿化的作用.对OA各种生物学功能的进一步研究将为诊断及治疗多种临床疾病提供新的靶点.
Osteoactivin(OA)시일충최선재골경화동물모형중발현적신형당단백.근년래연구표명,OA재골、간장、신장등조직중균유불동정도적표체,동시구유다충생물학공능,여성골세포분화이급파골세포생장、성섬유세포분화등.OA가유도성골세포급파골세포분화,제시기재골합성대사방면구유중요작용.단지유소량연구보도료OA작용적가능궤제,례여재성섬유세포중통과세포외신호조절격매신호통로,유도기질금속단백매(MMP)-3적표체이급작위일개하유조절제,삼여조절골형태발생단백(BMP)-2대성골세포분화여기질광화적작용.대OA각충생물학공능적진일보연구장위진단급치료다충림상질병제공신적파점.
Osteoactivin (OA) is a novel glycoprotein that was identificated from an animal model of osteosclerosis. Recent studies show that OA is expressed in bone,liver,and kidney with different levels,and takes many biological functions, such as osteoblast and osteoclast growth and differentiation, fibroblasts cell differentiation. OA plays an important role in bone anabolism by inducing the differentiation of osteoblast and osteoclast. But only a few studies reported the possible mechanism of OA ,such as induction of matrix metallo-proteinase(MMP)-3 expression through extracellular signal-regulated kinase signaling pathway in fibroblast cells, as well as a downstream regulator, involved in the regulation of bone morphogenetic protein (BMP) -2 on osteoblast differentiation and matrix mineralization. Investigating the mechanisms by which OA mediates its biological roles will open the door for developing novel therapeutic as well as diagnostic tools for various clinical conditions.