肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2008年
3期
155-157
,共3页
PPARγ%胃肿瘤%MGC803细胞%肿瘤移植%生长%抑制
PPARγ%胃腫瘤%MGC803細胞%腫瘤移植%生長%抑製
PPARγ%위종류%MGC803세포%종류이식%생장%억제
PPAR gamma%Stomach neoplasms%MGC803%Neoplasm transplantation%Growth%Inhibition
目的 探讨过氧化酶体增生物激活受体γ(PPARγ)配体罗格列酮对小鼠体内人类胃癌MGC803细胞移植瘤生长的影响.方法 建立人类胃癌MGC803细胞小鼠肾囊膜下移植瘤模型,通过解剖显微镜和HE染色观察50 mg/kg的罗格列酮连续灌胃5 d作用于荷瘤小鼠后对移植瘤生长的抑制作用.结果 50 mg/kg的罗格列酮能明显抑N4,鼠肾囊膜下移植瘤MGC803细胞增生、诱导肿瘤细胞凋亡而抑制移植瘤的生长,抑瘤率达62.9%.结论 PPARγ配体罗格列酮能抑制小鼠体内肾囊膜下MGC803细胞移植瘤生长.
目的 探討過氧化酶體增生物激活受體γ(PPARγ)配體囉格列酮對小鼠體內人類胃癌MGC803細胞移植瘤生長的影響.方法 建立人類胃癌MGC803細胞小鼠腎囊膜下移植瘤模型,通過解剖顯微鏡和HE染色觀察50 mg/kg的囉格列酮連續灌胃5 d作用于荷瘤小鼠後對移植瘤生長的抑製作用.結果 50 mg/kg的囉格列酮能明顯抑N4,鼠腎囊膜下移植瘤MGC803細胞增生、誘導腫瘤細胞凋亡而抑製移植瘤的生長,抑瘤率達62.9%.結論 PPARγ配體囉格列酮能抑製小鼠體內腎囊膜下MGC803細胞移植瘤生長.
목적 탐토과양화매체증생물격활수체γ(PPARγ)배체라격렬동대소서체내인류위암MGC803세포이식류생장적영향.방법 건립인류위암MGC803세포소서신낭막하이식류모형,통과해부현미경화HE염색관찰50 mg/kg적라격렬동련속관위5 d작용우하류소서후대이식류생장적억제작용.결과 50 mg/kg적라격렬동능명현억N4,서신낭막하이식류MGC803세포증생、유도종류세포조망이억제이식류적생장,억류솔체62.9%.결론 PPARγ배체라격렬동능억제소서체내신낭막하MGC803세포이식류생장.
Objective To investigate the inhibitory effects of PPARγ ligand rosiglitazone in vivo of mice which were transplanted the human gastric carcinoma cells line MGC803 into subrenal-capsule.Methods To establish kunming mouse tumor modles of MGC803 cells transplanted into subrenal-capsule and assay the inhibiting growth effects of 50 mg／kg rosiglitazone which were continuously poured into mice gastric for five days by the dissect microscope and HE stain.Results Rosiglitazone could inhibit the growth of MGC803 cells transplanted into subrenal-capsule of mice in vivo by inhibiting proliferation and inducting apoptosis,the tumor inhibitory rate was 62.9％.Conclusion PPARγ ligand rosiglitazone can inhibit the growth of MGC803 cells transplanted into subrenal-capsule of mice in vivo.
