CAJ | 학술논문

目的:探讨特异性免疫治疗对变应性鼻炎(AR)伴(不伴)哮喘患者的临床疗效.方法:155例患者,其中AR伴哮喘者40例,均符合免疫治疗入选标准,分为免疫治疗组及对照组.AR 伴或不伴哮喘者分别进行观察.免疫治疗组以安脱达屋尘螨疫苗行特异性免疫治疗,对照组行单纯对症药物治疗.所有患者在治疗初始时记录鼻部及哮喘症状得分、用药得分、生活质量影响程度,1年观察结束后回访以上指标,并进行主观症状改善评价.结果:AR伴哮喘者免疫治疗组治疗1年后其鼻部及哮喘症状得分、用药得分、生活质量影响程度较治疗前明显改善,与对照组相比亦有明显差异.对照组中除用药得分外,其余指标治疗1年前后均未见明显差异.AR不伴哮喘者免疫治疗组及对照组治疗1年后其鼻部症状得分、用药得分、生活质量影响程度均较治疗前有显著改善,但免疫治疗组改善程度强于对照组.结论:AR伴哮喘者在临床上行单纯药物治疗疗效不佳,而行SIT可取得极佳的临床疗效.
목적:탐토특이성면역치료대변응성비염(AR)반(불반)효천환자적림상료효.방법:155례환자,기중AR반효천자40례,균부합면역치료입선표준,분위면역치료조급대조조.AR 반혹불반효천자분별진행관찰.면역치료조이안탈체옥진만역묘행특이성면역치료,대조조행단순대증약물치료.소유환자재치료초시시기록비부급효천증상득분、용약득분、생활질량영향정도,1년관찰결속후회방이상지표,병진행주관증상개선평개.결과:AR반효천자면역치료조치료1년후기비부급효천증상득분、용약득분、생활질량영향정도교치료전명현개선,여대조조상비역유명현차이.대조조중제용약득분외,기여지표치료1년전후균미견명현차이.AR불반효천자면역치료조급대조조치료1년후기비부증상득분、용약득분、생활질량영향정도균교치료전유현저개선,단면역치료조개선정도강우대조조.결론:AR반효천자재림상상행단순약물치료료효불가,이행SIT가취득겁가적림상료효.
Objective:To evaluate the efficacy of specific immunotherapy (SIT) with standardized dermatophagoides pteronyssinus extract for allergic rhinitis (AR)accompanied with asthma.Method:One hundred and fifty-five patients(40 AR with asthma, AR & asthma) in accordance with the inclusion criteria of SIT, were allocated to receive standardized Dermatophagoides pteronyssinus extract (SIT group, n=89) or medical treatment(control group, n=66). AR with or without asthma was observed separately. Symptom and medicine scores, quality of life were recorded and analyzed before and after 1 year treatment. Side effects were registered. Subjective evaluation of symptoms was made by the patients.Result:Rhinitis and asthma symptom scores, medicine scores and quality of life were greatly improved in SIT group of AR & asthma after 1 year, which were not significant changed in control group except for medicine scores. The subjective evaluation of symptoms was also significantly improved in SIT group. In patients of AR without asthma, the symptom scores, medicine scores and quality of life were both improved. The SIT group improved greater than that of control group.Conclusion:The clinical efficacy of patients with AR & asthma was not good with simple medical treatment, while great clinical efficacy could be acquired with SIT.