CAJ | 학술논문

浆细胞样树突状细胞(pDC)是体内产生干扰素(IFN)-α最有力的细胞,并且是固有免疫和适应性免疫之间的重要联系.HIV-1感染者产生IFN-α不足,循环中pDC数量减少并且功能缺陷,其机制尚不明确.IFN-α在HIV感染中是有益还是有害目前仍存在争论.pDC数量和功能的平衡在HIV发病中起重要作用,利用pDC绝对计数和功能检测作为HIV-1感染者生物标记有潜在价值.
장세포양수돌상세포(pDC)시체내산생간우소(IFN)-α최유력적세포,병차시고유면역화괄응성면역지간적중요련계.HIV-1감염자산생IFN-α불족,순배중pDC수량감소병차공능결함,기궤제상불명학.IFN-α재HIV감염중시유익환시유해목전잉존재쟁론.pDC수량화공능적평형재HIV발병중기중요작용,이용pDC절대계수화공능검측작위HIV-1감염자생물표기유잠재개치.
Plasmacytoid dendritic cells (pDC) produce high levels of interferon (IFN)-α in response to viral infection in humans and act as an important link between innate and adaptive immunity. IFN-α production in patients infected with HIV-1 is deficient. The mechanisms for the decreased circulating pDC and their dysfunction in HIV-infected patients are unknown. Whether IFN-α is beneficial or detrimental in HIV infection remains a matter of debate. The balance between pDC numbers and function is important in the pathogenesis of HIV-1 infection. Therefore, using absolute pDC counts and function as a biomarker, along with CD4+ cell counts and viral load in HIV-1-infected patients has potential value.