CAJ | 학술논문

目的研究感染性和自身免疫性两类炎症中血小板源生长因子(PDGF)、血管内皮生长因子(VEGF)的异常变化及变化持续时间方面的差异.方法应用ELISA法于不同时间检测149例两类炎症患者血清各因子含量值共7次,比较各因子变化情况及变化持续时间.结果 PDGF:治疗前感染组(6.32±2.54)μg/ml,免疫组(2.57±1.65)μg/ml,差异有统计学意义(P<0.05).其组间、组内不同时间点及各组间对应时点差异均有统计学意义(P均<0.05).VEGF:治疗前感染组(179.5±53.30)ng/ml,免疫组(221.4±70.04)ng/ml,差异有统计学意义(P<0.05).其组间、组内不同时间点及各组间对应时点差异均有统计学意义(P均<0.05).2组生长因子水平达峰值时间[PDGF:感染组(2.6±1.1)d,免疫组(5.4±3.3)d;VEGF:感染组(2.4±0.7)d,免疫组(7.2±3.3)d],差异均有统计学意义(P<0.05).异常变化持续时间PDGF:感染组(6.7±3.1)d,免疫组(15.4±6.1)d.VEGF:感染组(8.1±3.4)d,免疫组(16.7±7.2)d,差异均有统计学意义(P均<0.05).结论两类炎症中两种细胞因子异常变化水平及异常变化持续时间均有显著差异,这种差异与炎症的性质及结局可能有内在因果关系.
목적 연구감염성화자신면역성량류염증중혈소판원생장인자(PDGF)、혈관내피생장인자(VEGF)적이상변화급변화지속시간방면적차이.방법 응용ELISA법우불동시간검측149례량류염증환자혈청각인자함량치공7차,비교각인자변화정황급변화지속시간.결과 PDGF:치료전감염조(6.32±2.54)μg/ml,면역조(2.57±1.65)μg/ml,차이유통계학의의(P<0.05).기조간、조내불동시간점급각조간대응시점차이균유통계학의의(P균<0.05).VEGF:치료전감염조(179.5±53.30)ng/ml,면역조(221.4±70.04)ng/ml,차이유통계학의의(P<0.05).기조간、조내불동시간점급각조간대응시점차이균유통계학의의(P균<0.05).2조생장인자수평체봉치시간[PDGF:감염조(2.6±1.1)d,면역조(5.4±3.3)d;VEGF:감염조(2.4±0.7)d,면역조(7.2±3.3)d],차이균유통계학의의(P<0.05).이상변화지속시간PDGF:감염조(6.7±3.1)d,면역조(15.4±6.1)d.VEGF:감염조(8.1±3.4)d,면역조(16.7±7.2)d,차이균유통계학의의(P균<0.05).결론 량류염증중량충세포인자이상변화수평급이상변화지속시간균유현저차이,저충차이여염증적성질급결국가능유내재인과관계.
Objective To evaluate the changes of platelet-derived growth factor(PDGF) and vascular endo-thelial growth factor(VEGF) in infectious and autoimmunity diseaases. Methods The growth factors were measured by ELISA in 149 patients for seven times in different periods,and the levels and duration were compared. Results PDGF was (6.32±2.54) μg/ml and (2.57±1.65) μg/ml (P<0.05), and VEGF was (179.5±53.30) ng/ml and (221.4±70.04) ng/ml(P<0.05) in the two groups before treatment;There was statistical significance in dif-ferent time points between groups and within groups for PDGF(P<0.05) and significant difference for time chan-ging to the peak and changed duration between two groups for VEGF(P<0.05). For the two groups,the peak time of PDGF were (2.6±1.1) and (5.4±3.3) days;The peak time of VEGF were (2.4±0.7) and (7.2±3.3) days respectively(P<0.05 for each). However in the two groups, the change duration were (6.7±3.1) and (15.4±6.1) days for PDGF and (8.1±3.4) and (16.7±7.2) days for VEGF (P<0.05 for each). Conclu-sions There is significant difference for serum levels of PDGF and VEGF and the level change duration as well in the two groups, which maybe correlated with inflammatory nature and outcome.