CAJ | 학술논문

目的探讨光学相干断层扫描(optical coherence tomography,OCT)测量黄斑厚度对青光眼的诊断价值.方法采用OCT2000型对正常人42例(60)和原发性开角型青光眼患者43例(66眼)的黄斑区厚度进行测量,观察两组人群黄斑厚度地形图的图像特征;并将止常人和青光眼患者黄斑厚度值进行比较;用受试者特征曲线下面积(area under the receive operator characteristic curve,AROC)的分析方法找出青光眼早期诊断的最佳指标.结果正常人黄斑厚度地形图呈"马蹄形",青光眼患者"马蹄形"特征不典型或"马蹄形"特征消失;青光眼患者黄斑各分区视网膜厚度均比止常人减少,差异有统计学意义(P＜0.05);早期青光眼患者的黄斑外环各分区厚度也较正常人减少,差异也有统计学意义(P＜0.05);正常人和青光眼患者之间比较,黄斑下方外环区的AROC值最大(早期青光眼患者为0.719;青光眼患者为0.881),表明该指标对青光眼的诊断价值最大.结论 OCT测量黄斑厚度是青光眼诊断和早期诊断的新型敏感的有效手段.
목적 탐토광학상간단층소묘(optical coherence tomography,OCT)측량황반후도대청광안적진단개치.방법 채용OCT2000형대정상인42례(60)화원발성개각형청광안환자43례(66안)적황반구후도진행측량,관찰량조인군황반후도지형도적도상특정;병장지상인화청광안환자황반후도치진행비교;용수시자특정곡선하면적(area under the receive operator characteristic curve,AROC)적분석방법조출청광안조기진단적최가지표.결과 정상인황반후도지형도정"마제형",청광안환자"마제형"특정불전형혹"마제형"특정소실;청광안환자황반각분구시망막후도균비지상인감소,차이유통계학의의(P＜0.05);조기청광안환자적황반외배각분구후도야교정상인감소,차이야유통계학의의(P＜0.05);정상인화청광안환자지간비교,황반하방외배구적AROC치최대(조기청광안환자위0.719;청광안환자위0.881),표명해지표대청광안적진단개치최대.결론 OCT측량황반후도시청광안진단화조기진단적신형민감적유효수단.
Objective To determine the diagnosis of measurement of macular thickness with optical cohercnce tomography(OCT) in glaucoma.Methods OCT was used to measure the macular thickness in 60 eyes of 42 normal persons and 66 eyes of 43 patients with glaucoma.Observing the image feature of macular thickness mapping in normal persons and glaucoma patients comparing the macular thickness between both groups,finding the strongest discriminating power parameter for glaucoma detection by area under the receive operator characteristic curve.Results The macular thickness mapping in normal persons was"house shoe" shaped.Diffuse on local thinning of macular thickness was shown in glaucoma patients.All macular parameters were statistically signifieantly different compared with normal subjects and glaucoma(P＜0.05).Macular outer ring in four quadrants,total macular volume were statistically significantly different comparing normal subjects and early glaucoma (P＜0.05).The highest AROC was maeular inferior outer ring between normal persons and slaucoma patients (0.881 and 0.719 respectively).Conclusion Measurement of macular thickness with OCT is effective in early diagnosis of glaucoma.