CAJ | 학술논문

目的:探讨EMS1在喉癌组织中的表达及与各临床病理因素的关系.方法: 采用流式细胞术检测40例喉癌组织和40例相应癌旁组织中EMS1的表达,并以20例非喉癌患者喉部正常黏膜组织作对照.结果:喉癌组织中EMS1蛋白的表达量及阳性表达率均明显高于癌旁组织及正常喉黏膜组织(P＜0.05),癌旁组织及正常喉黏膜组织间的EMS1表达差异无统计学意义(P＞0.05).EMS1蛋白的表达与喉癌组织中的淋巴结转移、临床分期、分化程度差异有统计学意义(P＜0.05);与临床分型、肿瘤大小、吸烟量、年龄和性别差异无统计学意义(P＞0.05).结论:EMS1蛋白的高表达可促进喉癌的发生、发展,其蛋白检测可作为判断喉癌分化、浸润、转移、分期的重要指标.
목적:탐토EMS1재후암조직중적표체급여각림상병리인소적관계.방법: 채용류식세포술검측40례후암조직화40례상응암방조직중EMS1적표체,병이20례비후암환자후부정상점막조직작대조.결과:후암조직중EMS1단백적표체량급양성표체솔균명현고우암방조직급정상후점막조직(P＜0.05),암방조직급정상후점막조직간적EMS1표체차이무통계학의의(P＞0.05).EMS1단백적표체여후암조직중적림파결전이、림상분기、분화정도차이유통계학의의(P＜0.05);여림상분형、종류대소、흡연량、년령화성별차이무통계학의의(P＞0.05).결론:EMS1단백적고표체가촉진후암적발생、발전,기단백검측가작위판단후암분화、침윤、전이、분기적중요지표.
Objective: To investigate the expression of EMS1 in laryngeal carcinoma and its clinical signifi-cance. Method:The expression of EMS1 protein was measured in 40 samples of, 40 samples of para carcinoma tis-sues (which were near to cutting margin of laryngeal carcinoma tissuse over 0. 5 cm) ,and 20 samples of normal la-ryngeal mucosa as controls by Flow Cytometere( Epics-XL Ⅱ ). Results:The quantity and percentage of EMS1 pro-tein expression in laryngeal carcinoma tissues was significantly higher than those in para carcinoma and in normal laryngeal mucosa tissues respectively(P<0. 05). There was no significant expression difference between the para carcinoma tissues and normal laryngeal mucosa tissues. There were positive correlation between the expressions of EMS1 protein and metastasis, pathological grade and clinical stage in laryngeal carcinoma. But there were not rela-tionship with patients' clinical classification, tumor size, smoking history, age and sex. Conclusion: The high ex-pression of EMS1 may contribute to the carcinogenesis and development of laryngeal carcinoma. The expression of EMS1 protein is an important index of judging differentiation, infiltration, metastasis and staging of laryngeal car-cinoma.