CAJ | 학술논문

目的以丹参素钠和原儿茶醛为指标,研究丹参酚酸肠吸收特性.方法建立丹参素钠和原儿茶醛含量测定方法,采用大鼠在体肠吸收法,考察不同吸收部位、药物浓度、介质pH对丹参素钠和原儿茶醛吸收量的影响,考察吸收动力学参数.结果丹参素钠和原儿茶醛在小肠各段均有吸收,无特定吸收部位;在实验所设定的浓度范围内2种成分的吸收量均与浓度呈现出良好的线性关系,没有吸收饱和现象发生;pH值对丹参素钠的肠吸收量没有显著影响,而对原儿茶醛有影响;丹参素钠吸收速率常数Ka 0.3996 h~(-1),T_(1/2) 1.734 h,原儿茶醛吸收速率常数Ka 0.4019 h~(-1),T_(1/2) 1.724 h.结论丹参酚酸在肠道中吸收良好,吸收机制为被动扩散.
목적 이단삼소납화원인다철위지표,연구단삼분산장흡수특성.방법 건립단삼소납화원인다철함량측정방법,채용대서재체장흡수법,고찰불동흡수부위、약물농도、개질pH대단삼소납화원인다철흡수량적영향,고찰흡수동역학삼수.결과 단삼소납화원인다철재소장각단균유흡수,무특정흡수부위;재실험소설정적농도범위내2충성분적흡수량균여농도정현출량호적선성관계,몰유흡수포화현상발생;pH치대단삼소납적장흡수량몰유현저영향,이대원인다철유영향;단삼소납흡수속솔상수Ka 0.3996 h~(-1),T_(1/2) 1.734 h,원인다철흡수속솔상수Ka 0.4019 h~(-1),T_(1/2) 1.724 h.결론 단삼분산재장도중흡수량호,흡수궤제위피동확산.
Objection To study the intestinal absorptive features of salvianolic acid taking salvianic acid A sodium and protocatechuic aldehyde as the indexes. Methods The method of intestinal absorption was applied in vivo in rats for establishing a quantitative determination of salvianic acid A sodium and protocatechuic aldehyde. The influences of different absorptive segments of intestines, drug concentrations and pH conditions on the intestinal absorptive volume of salvianic acid A sodium and protocatechuic aldehyde were observed, and the parameter of absorptive dynamics was studied. Results There was no specified absorptive segments of intestines. The absorptive volume had a good linear relationship in the range of test concentration without saturation. The value of pH had no influence on intestinal absorption of salvianic acid A sodium, but had on protocatechuic aldehyde. The absorptive rate constant of salvianic acid A sodium (Ka) was 0.3996 h~(-1) and T_(1/2) was 1.734 h, and that of protocatechuic aldehyde, 0.401 9 h~(-1) and T_(1/2), 1.724 h. Conclusion Salvianolic acid can be absorbed well in the intestines, and the mechanism is that the absorption is in a passive diffusion way.