中国病理生理杂志
中國病理生理雜誌
중국병리생리잡지
CHINESE JOURNAL OF PATHOPHYSIOLOGY
2010年
3期
605-607,612
,共4页
热休克蛋白质70羧基端相互作用蛋白%泛素-蛋白酶体系统%心肌再灌注损伤
熱休剋蛋白質70羧基耑相互作用蛋白%汎素-蛋白酶體繫統%心肌再灌註損傷
열휴극단백질70최기단상호작용단백%범소-단백매체계통%심기재관주손상
Carboxyl terminus of the HSP70-interacting protein%Ubiquitin-proteasome system%Myocardial reperfusion injury
Carboxyl terminus of the HSP70-interacting protein (CHIP) is a co-chaperone of HSPs as well as an E3 ubiquitin ligase, and it is the connexin between heat shock proteins and ubiquitin-proteasome system. Recent research discovered that CHIP also possesses an intrinsic chaperone activity that enables it to recognize and bind nonnative proteins independently. CHIP regulates the HSPs expression and activity, and facilitates the client proteins ubiquitination and subsequent proteasome-dependent degradation. CHIP also inhibits apoptosis through MAPKs signaling pathways, and affects eNOS specific activity by means of the effects on Akt. Moreover, CHIP plays an important role in mitochondrial oxidative stress protection. With these above points, this paper reviews the function of CHIP in myocardial ischemia/reperfusion injury.
