CAJ | 학술논문

人类泛素耦联酶E2C(UBE2C)属于泛素.蛋白酶体途径的E2酶家族,其通过调控cyclinA和cyclin B的周期性变化在维持细胞周期的正常运转中起着重要作用.UBE2C通过其N末端来控制细胞周期末期促进复合物(APC)的激活阈值,并加强对APC检查点的调节,而UBE2C的细胞周期依赖性表达又受APC的调控.UBE2C在多种肿瘤细胞株和组织中高表达,与肿瘤的发生、增殖、转化以及恶性程度密切相关,可作为肿瘤的诊断和治疗的新靶点.
인류범소우련매E2C(UBE2C)속우범소.단백매체도경적E2매가족,기통과조공cyclinA화cyclin B적주기성변화재유지세포주기적정상운전중기착중요작용.UBE2C통과기N말단래공제세포주기말기촉진복합물(APC)적격활역치,병가강대APC검사점적조절,이UBE2C적세포주기의뢰성표체우수APC적조공.UBE2C재다충종류세포주화조직중고표체,여종류적발생、증식、전화이급악성정도밀절상관,가작위종류적진단화치료적신파점.
Human ubiquitin-conjugating enzyme E2C (UBE2C), a member of E2 enzyme family of ubiquitin-proteasome pathway, plays an important role in maintaining the cell cycle running normally by regula-ting the cyclical variation of cyclin A and eyelin B. The N terminus of the UBE2C controls the threshold for ana-phase-promoting complex(APC)activation and enhances checkpoint regulation of the APC. Otherwise, the cell cycle-dependent expression of UBE2C is regulated by APC. UBE2C overexpressed in many kinds of tumor cell lines and tissues is closely related to the development, proliferation, transformation and malignant degree of cancer. UBE2C may be regarded as a new diagnostic and therapeutic target.