CAJ | 학술논문

紫杉醇类、长春碱类、铂类、沙利度胺及新药硼替佐米等常用化疗药物常可导致周围神经病变.预防或治疗化疗药物所致周围神经病变且不影响疗效的动物实验或临床试验相继进行,钙镁灌注、谷胱甘肽、硫辛酸等的应用研究也不断进展.
자삼순류、장춘감류、박류、사리도알급신약붕체좌미등상용화료약물상가도치주위신경병변.예방혹치료화료약물소치주위신경병변차불영향료효적동물실험혹림상시험상계진행,개미관주、곡광감태、류신산등적응용연구야불단진전.
Chemotherapy- induced peripheral neuropathy (CIPN) can be caused by many commonly used chemotherapeutic agents, such as taxanes, vinca alkaloids, platinum drugs, thalidomide,and also by newer agents such as bortezomib. Both animal experiments and clinical studies are being conducted to investigate strategies for preventing CIPN or ameliorating established CIPN without affecting the antitumor efficacy of chemotherapy. Treatments using calcium and magnesium infusions,glutathione,lipoid acid are being evaluated for their clinical application.