中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2010年
11期
1482-1484
,共3页
结肠肿瘤/代谢%微管相关蛋白质类/代谢%DNA结合蛋白质类/代谢%核蛋白质类/代谢
結腸腫瘤/代謝%微管相關蛋白質類/代謝%DNA結閤蛋白質類/代謝%覈蛋白質類/代謝
결장종류/대사%미관상관단백질류/대사%DNA결합단백질류/대사%핵단백질류/대사
Colonic neoplasms/ME%Microtubule-associated proteins/ME%DNA-binding proteins/ME%Nuclear proteins/ME
目的 探讨P73和Survivin在结肠癌中的表达及临床意义.方法 应用免疫组化方法检测46例结肠癌组织、12例正常结肠黏膜组织中P73及Survivin的表达.结果 结肠癌与正常结肠黏膜组织中P73阳性表达率分别为67.4%和8.3%,二者阳性率表达比较差异有统计学意义(χ2=13.42,P＜0.01);淋巴结转移灶组的P73阳性率明显高于结肠癌原发灶组(P＜0.01),P73表达与结肠癌的Dukes分期有关(χ2=8.01,P＜0.01).P73与Survivin在结肠癌中的表达呈正相关(rs=0.487,P＜0.01).结论 P73与Survivin在结肠癌中的表达密切相关,其参与了结肠癌的发生及发展,可作为判断其转移及预后的参考指标.
目的 探討P73和Survivin在結腸癌中的錶達及臨床意義.方法 應用免疫組化方法檢測46例結腸癌組織、12例正常結腸黏膜組織中P73及Survivin的錶達.結果 結腸癌與正常結腸黏膜組織中P73暘性錶達率分彆為67.4%和8.3%,二者暘性率錶達比較差異有統計學意義(χ2=13.42,P＜0.01);淋巴結轉移竈組的P73暘性率明顯高于結腸癌原髮竈組(P＜0.01),P73錶達與結腸癌的Dukes分期有關(χ2=8.01,P＜0.01).P73與Survivin在結腸癌中的錶達呈正相關(rs=0.487,P＜0.01).結論 P73與Survivin在結腸癌中的錶達密切相關,其參與瞭結腸癌的髮生及髮展,可作為判斷其轉移及預後的參攷指標.
목적 탐토P73화Survivin재결장암중적표체급림상의의.방법 응용면역조화방법검측46례결장암조직、12례정상결장점막조직중P73급Survivin적표체.결과 결장암여정상결장점막조직중P73양성표체솔분별위67.4%화8.3%,이자양성솔표체비교차이유통계학의의(χ2=13.42,P＜0.01);림파결전이조조적P73양성솔명현고우결장암원발조조(P＜0.01),P73표체여결장암적Dukes분기유관(χ2=8.01,P＜0.01).P73여Survivin재결장암중적표체정정상관(rs=0.487,P＜0.01).결론 P73여Survivin재결장암중적표체밀절상관,기삼여료결장암적발생급발전,가작위판단기전이급예후적삼고지표.
Objective To study the expression of P73 and its relationship with expression of Survivin in colon carcinoma. Methods The expression of P73 and Survivin was studied by immunohistochemical technique in 46 cases of colon carcinoma and 12 cases of normal colon mucosa. Results The P73 expression rate of colon carcinoma was significant higher than that of normal colon mucosa(χ2 = 13.42, P ＜0.01 ). Overexpression of P73 was related to the pathological grade and Dukes stage ( ( χ2 = 8.01, P ＜0.01 ), and it was closely related to lymphatic metastasis of colon carcinoma( P ＜0.01 ). There was a positive relation between P73 and Survivin( rs =0.487, P ＜0.01 ). Conclusions The expression of P73 was closely associated with Survivin in colon carcinoma. The results suggested that the overexpression of P73 and Survivin was involved in the tumorigenesis and development of colon carcinoma and P73 and Survivin might be used as a new tumor marker in metastasis and prognosis of colon carcinoma.
