中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2008年
4期
333-336
,共4页
年龄相关性黄斑变性%危险因素%病例对照研究
年齡相關性黃斑變性%危險因素%病例對照研究
년령상관성황반변성%위험인소%병례대조연구
Age related macular degeneration%Risk factors%Case-control study
目的 探讨年龄相关性黄斑变性(简称AMD)发生的可能相关危险因素.方法 应用成组对照的病例对照研究方法.病例组为AMD患者85例,选取医院中非AMD患者i00例作为对照组,均进行标准问卷调查及相关眼科检查,收集有关人口统计信息及危险因素的暴露史.采用)x2检验和多因素非条件Logistic逐步回归模型进行分析,筛选AMD的主要危险因素.结果 进行Logistic逐步回归分析,最终进入模型的因素有吸烟(X1)、抗氧化剂摄入(X2)、高血压(X3),建立回归方程为:ln[P/(1-P)]=-0.485+0.778 X1-0.897 X2+0.694 X3.多因素分析发现,吸烟(OR=2.177,95%CI=1.167～4.062)和高血压(OR=2.001,95%CI=1.063～3.766)为AMD发生的危险因素;经常服用抗氧化剂(OR=0.408,95%CI=0.200～0.832)为AMD发生的保护因素.趋势性检验发现吸烟与AMD的优势比之间存在一定的剂量反应关系.结论 AMD是多因素综合作用所致,吸烟及高血压会增加患AMD危险性,抗氧化剂的使用会减少患AMD的危险性.
目的 探討年齡相關性黃斑變性(簡稱AMD)髮生的可能相關危險因素.方法 應用成組對照的病例對照研究方法.病例組為AMD患者85例,選取醫院中非AMD患者i00例作為對照組,均進行標準問捲調查及相關眼科檢查,收集有關人口統計信息及危險因素的暴露史.採用)x2檢驗和多因素非條件Logistic逐步迴歸模型進行分析,篩選AMD的主要危險因素.結果 進行Logistic逐步迴歸分析,最終進入模型的因素有吸煙(X1)、抗氧化劑攝入(X2)、高血壓(X3),建立迴歸方程為:ln[P/(1-P)]=-0.485+0.778 X1-0.897 X2+0.694 X3.多因素分析髮現,吸煙(OR=2.177,95%CI=1.167～4.062)和高血壓(OR=2.001,95%CI=1.063～3.766)為AMD髮生的危險因素;經常服用抗氧化劑(OR=0.408,95%CI=0.200～0.832)為AMD髮生的保護因素.趨勢性檢驗髮現吸煙與AMD的優勢比之間存在一定的劑量反應關繫.結論 AMD是多因素綜閤作用所緻,吸煙及高血壓會增加患AMD危險性,抗氧化劑的使用會減少患AMD的危險性.
목적 탐토년령상관성황반변성(간칭AMD)발생적가능상관위험인소.방법 응용성조대조적병례대조연구방법.병례조위AMD환자85례,선취의원중비AMD환자i00례작위대조조,균진행표준문권조사급상관안과검사,수집유관인구통계신식급위험인소적폭로사.채용)x2검험화다인소비조건Logistic축보회귀모형진행분석,사선AMD적주요위험인소.결과 진행Logistic축보회귀분석,최종진입모형적인소유흡연(X1)、항양화제섭입(X2)、고혈압(X3),건립회귀방정위:ln[P/(1-P)]=-0.485+0.778 X1-0.897 X2+0.694 X3.다인소분석발현,흡연(OR=2.177,95%CI=1.167～4.062)화고혈압(OR=2.001,95%CI=1.063～3.766)위AMD발생적위험인소;경상복용항양화제(OR=0.408,95%CI=0.200～0.832)위AMD발생적보호인소.추세성검험발현흡연여AMD적우세비지간존재일정적제량반응관계.결론 AMD시다인소종합작용소치,흡연급고혈압회증가환AMD위험성,항양화제적사용회감소환AMD적위험성.
Objective To explore the possible risk factors of age related macular degeneration(AMD).Method A group comparing case-control study was carried out.The cases were eighty-five AMD.The controls were one hundred subjects without AMD.All the participants underwent stardard questionnaire survey and correlative eye examination.Uniform questionnaires were administered to obtain demographic information and exposure information of related factors.Statistical analysis of x2 test and multi-factors non-conditional Logistic regression were performed to screen the risk factors.Results:Statistical analysis of Logistic regression displayed that ultimate factors,such as smoking(X1),taking antioxidant(X2)and hypertension(X3)entered the model.The established regression equation was ln[P/(1-P)]=-0.485+0.778 X1-0.897 X,+0.694 X1.The multi-factors Logistic regression show that smoking(OR=2.177,95%CI=1.167～4.062)and hypertension(OR=2.001,95%CI=1.063～3.766)are risk factors for AMD,while taking antioxidant regularly(OR=0.408,95%CI=0.200～0.832)is a protective factor.The dose-response were observed between smoking and odds ratio of AMD by fiend test.Conclusions AMD is caused by many kinds of factors.Smoking and hypertension can increase the risk of AMD,while taking antioxidant regularly can reduce the risk of AMD.
