中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2009年
2期
85-88
,共4页
柯晓燕%汤天宇%洪珊珊%邹冰%储康康%周振宇%杭跃跃%李惠国%阮宗才%陆祖宏
柯曉燕%湯天宇%洪珊珊%鄒冰%儲康康%週振宇%杭躍躍%李惠國%阮宗纔%陸祖宏
가효연%탕천우%홍산산%추빙%저강강%주진우%항약약%리혜국%원종재%륙조굉
孤独性障碍%脑%磁共振成像,弥散%各向异性%白质
孤獨性障礙%腦%磁共振成像,瀰散%各嚮異性%白質
고독성장애%뇌%자공진성상,미산%각향이성%백질
Autistic disorder%Brain%Diffusion magnetic resonance imaging%Anisotropy%White matter
目的 分析高功能孤独症患儿的全脑白质纤维的完整性.方法 对18例高功能孤独症患儿(病例组)以及10名年龄、性别、智商与病例组相匹配的健康儿童(对照组)进行全脑弥散张量成像(DTI)测量;应用基于体素的分析方法,比较两组全脑各向异性分数(FA)的差异.使用Spearman相关分析,分析病例组各感兴趣区FA值与儿章期孤独症评定表(CARS)总分及各项目之间的关系.结果 与对照组相比,病例组右侧额下回、左侧额中回及右侧颞下回邻近白质的FA值低(分别为0.67±0.10、0.57±0.09、0.50 ±0.12),左顶上小叶邻近白质的FA值高(0.55±0.15;P<0.001).病例组左额中回邻近白质的FA值与CARS中的与非生命物体的关系的得分呈负相关(r=-0.63,P=0.005).结论 高功能孤独症患儿多个部位的脑白质纤维的完整性受到破坏.
目的 分析高功能孤獨癥患兒的全腦白質纖維的完整性.方法 對18例高功能孤獨癥患兒(病例組)以及10名年齡、性彆、智商與病例組相匹配的健康兒童(對照組)進行全腦瀰散張量成像(DTI)測量;應用基于體素的分析方法,比較兩組全腦各嚮異性分數(FA)的差異.使用Spearman相關分析,分析病例組各感興趣區FA值與兒章期孤獨癥評定錶(CARS)總分及各項目之間的關繫.結果 與對照組相比,病例組右側額下迴、左側額中迴及右側顳下迴鄰近白質的FA值低(分彆為0.67±0.10、0.57±0.09、0.50 ±0.12),左頂上小葉鄰近白質的FA值高(0.55±0.15;P<0.001).病例組左額中迴鄰近白質的FA值與CARS中的與非生命物體的關繫的得分呈負相關(r=-0.63,P=0.005).結論 高功能孤獨癥患兒多箇部位的腦白質纖維的完整性受到破壞.
목적 분석고공능고독증환인적전뇌백질섬유적완정성.방법 대18례고공능고독증환인(병례조)이급10명년령、성별、지상여병례조상필배적건강인동(대조조)진행전뇌미산장량성상(DTI)측량;응용기우체소적분석방법,비교량조전뇌각향이성분수(FA)적차이.사용Spearman상관분석,분석병례조각감흥취구FA치여인장기고독증평정표(CARS)총분급각항목지간적관계.결과 여대조조상비,병례조우측액하회、좌측액중회급우측섭하회린근백질적FA치저(분별위0.67±0.10、0.57±0.09、0.50 ±0.12),좌정상소협린근백질적FA치고(0.55±0.15;P<0.001).병례조좌액중회린근백질적FA치여CARS중적여비생명물체적관계적득분정부상관(r=-0.63,P=0.005).결론 고공능고독증환인다개부위적뇌백질섬유적완정성수도파배.
Objectlve To analysis the changes of white matter fiber in autistic disorder.Methods Diffusion tensor imaging(DTI)data were obtained from 18 autistic children and 10 age-,sex-and intelligent quotient matched normal controls.Voxel-based analysis Was applied to assess the fractional anisotropy(FA)in cerebral tissues.Results Compared with the controls,the FA values in autistic children were significantly decreased in the white matter of right inferior frontal gyrus,left middle frontal gyrus and right inferior temporal gyms,and increased in the white matter of left superior parietal lobule(P＜0.001).Furthermore.the white matter changes on left middie frontal gyrus were significandy correlated with the scores of Childhond Autism Rming Scale(CARS)in autistic children(r=-0.63,P=0.005).Conclusion The white matter integrity is probably disconnected in many brain regions in children with autistic disorder.
