中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2011年
1期
26-29
,共4页
吴龙章%陈素颖%曾少芳%潘美玉%许蕴仪
吳龍章%陳素穎%曾少芳%潘美玉%許蘊儀
오룡장%진소영%증소방%반미옥%허온의
分枝杆菌属%微生物敏感性试验%生物学鉴定法%药物评价
分枝桿菌屬%微生物敏感性試驗%生物學鑒定法%藥物評價
분지간균속%미생물민감성시험%생물학감정법%약물평개
Mycobacterium%Microbial sensitivity tests%Biological assay%Drugs evaluation
目的 对广州市1998年7月至2010年3月共计12年间分枝杆菌菌型与药物敏感性试验结果进行回顾性分析,为临床第一线治疗结核病提供可靠的科学依据.方法 对12年间在实验室中从各类标本共分离出的14 095株分枝杆菌按照中国防痨协会制定的"结核病诊断细菌学检验规程"进行菌型鉴定和药物敏感性试验,并采用x2检验方法对各组检测结果进行统计学分析.结果 1998年7月至2010年3月12年间共计培养出分枝杆菌14 095株.MTB分离出10 844株,分离率76.84%,非结核分枝杆菌(non-tuberculosis mycobacteria,NTM)共有3251株,分离率23.16%,与全国第4次结核病流行病学抽样调查11.1%的NTM阳性分离率结果相比,差异有统计学意义(x2=69.79,P<0.001);而MTB对异烟肼、利福平、链霉素和乙胺丁醇的总耐药率分别为:28.99%(2729/9413)、21.75%(2047/9413)、17.45%(1643/9413)和11.53%(1085/9413).结论 分枝杆菌对链霉素、利福平和异烟肼的耐受性仍有上升趋势的压力,而NTM的分离率有逐年增多的风险,应引起临床第一线的高度重视.
目的 對廣州市1998年7月至2010年3月共計12年間分枝桿菌菌型與藥物敏感性試驗結果進行迴顧性分析,為臨床第一線治療結覈病提供可靠的科學依據.方法 對12年間在實驗室中從各類標本共分離齣的14 095株分枝桿菌按照中國防癆協會製定的"結覈病診斷細菌學檢驗規程"進行菌型鑒定和藥物敏感性試驗,併採用x2檢驗方法對各組檢測結果進行統計學分析.結果 1998年7月至2010年3月12年間共計培養齣分枝桿菌14 095株.MTB分離齣10 844株,分離率76.84%,非結覈分枝桿菌(non-tuberculosis mycobacteria,NTM)共有3251株,分離率23.16%,與全國第4次結覈病流行病學抽樣調查11.1%的NTM暘性分離率結果相比,差異有統計學意義(x2=69.79,P<0.001);而MTB對異煙肼、利福平、鏈黴素和乙胺丁醇的總耐藥率分彆為:28.99%(2729/9413)、21.75%(2047/9413)、17.45%(1643/9413)和11.53%(1085/9413).結論 分枝桿菌對鏈黴素、利福平和異煙肼的耐受性仍有上升趨勢的壓力,而NTM的分離率有逐年增多的風險,應引起臨床第一線的高度重視.
목적 대엄주시1998년7월지2010년3월공계12년간분지간균균형여약물민감성시험결과진행회고성분석,위림상제일선치료결핵병제공가고적과학의거.방법 대12년간재실험실중종각류표본공분리출적14 095주분지간균안조중국방로협회제정적"결핵병진단세균학검험규정"진행균형감정화약물민감성시험,병채용x2검험방법대각조검측결과진행통계학분석.결과 1998년7월지2010년3월12년간공계배양출분지간균14 095주.MTB분리출10 844주,분리솔76.84%,비결핵분지간균(non-tuberculosis mycobacteria,NTM)공유3251주,분리솔23.16%,여전국제4차결핵병류행병학추양조사11.1%적NTM양성분리솔결과상비,차이유통계학의의(x2=69.79,P<0.001);이MTB대이연정、리복평、련매소화을알정순적총내약솔분별위:28.99%(2729/9413)、21.75%(2047/9413)、17.45%(1643/9413)화11.53%(1085/9413).결론 분지간균대련매소、리복평화이연정적내수성잉유상승추세적압력,이NTM적분리솔유축년증다적풍험,응인기림상제일선적고도중시.
Objective To improve evidence-based care in the management of tuberculosis, we retrospectively analyzed the bacterial types and drug sensitivity test results of mycobacteria in Guangzhou over the past twelve years (from July 1998 to March 2010). Methods Over these twelve years,a total of 14 095 mycobacterial strains isolated from different samples were subjected to type indentification and drug sensitivity tests according to the Standard Protocols of Laboratory Diagnostics for Tuberculosis by the Chinese Antituberculosis Association. Chi-square test was performed for statistical analyses for comparisons between groups. Results Of 14 095 strains of mycobacteria isolated, 10 844 strains (76. 84%) were MTB,and 3251 strains (23. 16%) were non-tuberculosis myocobateria (NTM). Compared with the result of the fourth national survey of tuberculosis epidemiology, which showed 11.1% of NTM, the one of our study was significantly different (x2 = 69. 79, P < 0. 001). Drug sensitivity tests of MTB showed tolerance rates of 28. 99% (2729/9413) ,21.75% (2047/9413), 17.45% (1643/9413) and 11.53% (1085/9413) against isoniazid, rifampin, streptomycin and ethambutol, respectively. Conclusion An increasing trend was observed in MTB drug tolerance against streptomycin, rifampin and isoniazid, whereas more and more NTM strains were isolated in recent years. These findings are worthy of note for clinicians.
