CAJ | 학술논문

目的:研究苦荞籽乙醇提取物的抗炎镇痛作用和急性毒性.方法:采用二甲苯致小鼠耳肿胀法和大鼠蛋清性足肿胀法规察抗炎作用;采用小鼠热板法和醋酸扭体法观察镇痛作用;用最大浓度,最大给药体积的药液灌胃给药.结果:苦荞籽提取物可明显抑制二甲苯所致小鼠耳廓的肿胀度,抑制蛋清所致大鼠足肿胀;可提高热板所致小鼠痛阈值,减少醋酸所致小鼠的扭体次数;最大给药量为374.5g/kg bw,相当于成人日用量的1498倍.结论:苦养籽提取物具有明显抗炎镇痛作用,无明显毒性.
목적:연구고교자을순제취물적항염진통작용화급성독성.방법:채용이갑분치소서이종창법화대서단청성족종창법규찰항염작용;채용소서열판법화작산뉴체법관찰진통작용;용최대농도,최대급약체적적약액관위급약.결과:고교자제취물가명현억제이갑분소치소서이곽적종창도,억제단청소치대서족종창;가제고열판소치소서통역치,감소작산소치소서적뉴체차수;최대급약량위374.5g/kg bw,상당우성인일용량적1498배.결론:고양자제취물구유명현항염진통작용,무명현독성.
The aim of this research was to investigate the anti-inflammatory and analgesic effects and acute toxicity of extract from Tartary Buckwheat seed (TSE). The animal models were established through dimethylbenzene-induced mice and rat inflammatory models with egg white injection under the aponeurosis. The pain models were obtained by hot plate and acetic acid in mice.The maximum administration dosage of TSE were determined via i.g. route in mice. TSE was able to significantly inhibit the mice ear edema induced by dimethylbenzene and the rat hind paw edema induced by egg white. The pain in mice caused by acetic acid and hot plate were evidently suppressed by TSE. The maximum administration dosage was 374.5g of TSE given to mice per kilogram, equivalent to 1498 times of the daily administration dosage of human body. TSE has obvious anti-inflamma-tion and analgesia effect and no apparent toxicity.