CAJ | 학술논문

合成并表征了三个钌(II)多吡啶配合物[Ru(phen)2(7-CH3-dppz)]2+ (i)、[Ru(phen)2(7-F-dppz)]2+ (ii)和 [Ru(phen)2(7-CF3-dppz)]2+ (iii).利用光谱法和粘度实验研究了配合物与DNA的结合行为.结果表明3个配合物均以插入方式与DNA结合,其与DNA的亲和力顺序为(ii) > (i) > (iii).同时采用密度泛函(DFT)理论计算合理解释了3个配合物与DNA结合行为的差异.
합성병표정료삼개조(II)다필정배합물[Ru(phen)2(7-CH3-dppz)]2+ (i)、[Ru(phen)2(7-F-dppz)]2+ (ii)화 [Ru(phen)2(7-CF3-dppz)]2+ (iii).이용광보법화점도실험연구료배합물여DNA적결합행위.결과표명3개배합물균이삽입방식여DNA결합,기여DNA적친화력순서위(ii) > (i) > (iii).동시채용밀도범함(DFT)이론계산합리해석료3개배합물여DNA결합행위적차이.
Three Ru(II) polypyridyl complexes, [Ru(phen)2(7-CH3-dppz)]2+ (i), [Ru(phen)2(7-F-dppz)]2+ (ii) and [Ru(phen)2(7-CF3-dppz)]2+ (iii) have been synthesized and characterized by elemental analysis, ES-MS (electrospray mass spectra), 1HNMR. The DNA-binding behaviors of these complexes have been studied by spectroscopic methods and viscosity measurements. The results indicate that the three complexes all bind to CT-DNA (calf thymus DNA) in an intercalative mode, and the DNA-binding affinity follows the order of (ii) > (i) > (iii). Theoretical studies for these complexes have been also carried out with the density functional theory (DFT) method. The difference in the DNA-binding behaviors of three complexes can be reasonably explained by the DFT calculations.