CAJ | 학술논문

目的评价肿瘤坏死因子α(TNF-α)基因启动子区-308位点基因多态性与胃癌易感性.方法检索PubMed、EMBASE数据库、Cochrane图书馆(1966年至2009年7月)及万方、中国生物医学文献数据库(1979年至2009年7月)文献,收集TNF-α-308位点基因多态性与胃癌易感性的病例对照研究,共检索到39篇相关文献,26篇纳入研究.应用RevMan 4.2对各研究结果进行异质性检验和效应值合并.结果 26篇纳入本研究的文献中,共计有5225例胃癌患者和8473例(名)对照人群.总研究人群TNF-α-308位点基因G:A的OR=0.85(95%CI:0.76～0.96,P=0.01),AA:GG基因型OR值为1.19(95%CI:1.01～1.39,P=0.03).分层分析显示,东方人种G:A的OR=0.97(95%CI:0.75～1.26,P=0.84),西方人种G:A的OR=0.79(95%CI:0.70～0.89,P＜0.01),AA:GG基因型OR值为1.26(95%CI:1.04～1.52,P=0.02).非贲门胃癌患者G:A的OR=0.90(95%CI:0.79～1.02,P=0.10),幽门螺杆菌阳性胃癌患者G:A的OR=1.08(95%CI:0.62～1.88.P=0.79).结论西方人种TNF-α-308位点A等位基因及从基因型与胃癌遗传易感性相关,携带A等位基因患者增加罹患胃癌的风险.
목적 평개종류배사인자α(TNF-α)기인계동자구-308위점기인다태성여위암역감성.방법 검색PubMed、EMBASE수거고、Cochrane도서관(1966년지2009년7월)급만방、중국생물의학문헌수거고(1979년지2009년7월)문헌,수집TNF-α-308위점기인다태성여위암역감성적병례대조연구,공검색도39편상관문헌,26편납입연구.응용RevMan 4.2대각연구결과진행이질성검험화효응치합병.결과 26편납입본연구적문헌중,공계유5225례위암환자화8473례(명)대조인군.총연구인군TNF-α-308위점기인G:A적OR=0.85(95%CI:0.76～0.96,P=0.01),AA:GG기인형OR치위1.19(95%CI:1.01～1.39,P=0.03).분층분석현시,동방인충G:A적OR=0.97(95%CI:0.75～1.26,P=0.84),서방인충G:A적OR=0.79(95%CI:0.70～0.89,P＜0.01),AA:GG기인형OR치위1.26(95%CI:1.04～1.52,P=0.02).비분문위암환자G:A적OR=0.90(95%CI:0.79～1.02,P=0.10),유문라간균양성위암환자G:A적OR=1.08(95%CI:0.62～1.88.P=0.79).결론 서방인충TNF-α-308위점A등위기인급종기인형여위암유전역감성상관,휴대A등위기인환자증가리환위암적풍험.
Objective To assess the association between tumor necrosis factor-alpha(TNF-α)gene promoter region-308 gene polymorphisms and gastric cancer(GC)susceptibility.Methods Published work about TNF-α-308 and GC from PubMed,EMBASE,Cochrane library in English and from Wanfang,CBM in Chinese were searched for relevant articles published by the end of July,2009.Thirty-nine relevant articles were selected and 26 of them met the criteria.The correlated index was extracted for aggregate analysis in RevMan 4.2.Results There were 5225 GC patients and 8473 controls for TNF-α-308 in 26 papers.Overall,allele contrast(G:A and AA:GG)genotype of TNF-α-308 polymorphisms produced significant results in worldwide populations,the OR values were 0.85(95% CI:0.76-0.96 ,P=0.01)and 1.19(95%CI:1.01-1.39,P=0.03).Subgroup analysis showed that OR values of G:A and AA:GG in west population were 0.79(95 % CI:0.70-0.89,P ＜ 0.01)and 1.26(95 % CI:1.04-1.52,P = 0.02),while in east populations subgroup analysis,the OR was 0.97(95% CI:0.75-1.26,P= 0.84).No significant association was observed in non-cardia GC and Helicobacter pylori positive GC,the OR values were 0.90(95% CI:0.79-1.02,P=0.10)and 1.08(95% CI:0.62-1.88,P=0.79).Conclusion TNF-α-308 A allele and AA genotype were associated with a statistically significant increased risk of gastric cancer in western people.