世界胃肠病学杂志（英文版）
世界胃腸病學雜誌（英文版）
세계위장병학잡지（영문판）
WORLD JOURNAL OF GASTROENTEROLOGY
2006年
48期
7805-7809
,共5页
Coeliac disease%Screening%Endomysial antibody%Familial study%IgA deficiency%Prevalence%Tissue transglutaminase
AIM: To assess the level of undiagnosed coeliac disease (CD) in relatives of patients affected by the condition.METHODS: We collected blood from 914 relatives of probands. We screened these individuals by ELISA for IgA gnd IgG tTG antibodies, confirming any positive IgA tTG results with an IgA EMA and looked for evidence of IgA deficiency in those who were IgG tTG positive alone, and performed IgG1 EMA in these individuals.We undertook HLA typing where positive screening was found, and this confirmed a strong prevalence of HLADQ2 in the coeliac population. Follow-up small intestinal biopsy was undertaken in cases with positive serological screening, wherever possible.RESULTS: Use of this serological screening algorithm revealed a prevalence of undiagnosed CD in 5%-6% of first degree relatives of probands.CONCLUSION: Our data suggests that first degree relatives of individuals with CD should be screened for this condition.
