稀土学报(英文版)
稀土學報(英文版)
희토학보(영문판)
JOURNAL OF RARE EARTHS
2004年
2期
288-291
,共4页
李瑾%胡国武%欧阳砥%牛瑞芳%周永洽%申泮文
李瑾%鬍國武%歐暘砥%牛瑞芳%週永洽%申泮文
리근%호국무%구양지%우서방%주영흡%신반문
cytobiology%cerium%matrix metalloproteinases%malignant tumor%metastasis%rare earths
The effects of Ce4+ on cell survival,expression and activity of matrix metalloproteinase-9(MMP-9)with MTT colorimetry and gelatin zymography assays in human bladder carcinoma cell line was studied.The results indicate that the lower concentration of Ce4+(0.01 mmol*L-1)has no influence on cell growth,but inhibits extremely expression of MMP-9 and increases its activity,whereas the higher concentration of Ce4+(1.0 mmol*L-1)can inhibit all of them.The results raise the possibility that Ce4+ may have beneficial effects in attenuating invasion and metastasis of malignant tumors.
