中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2011年
4期
266-269
,共4页
周新人%刘永铭%杨琳%王晓玉%陈敏娟
週新人%劉永銘%楊琳%王曉玉%陳敏娟
주신인%류영명%양림%왕효옥%진민연
糖尿病,2型%尿白蛋白排泄率%C5a
糖尿病,2型%尿白蛋白排洩率%C5a
당뇨병,2형%뇨백단백배설솔%C5a
Diabetes mellitus, type 2%Urine albumin excretion rate% C5a
目的 探讨2型糖尿病患者血、尿补体活化片段C5a含量的变化与糖尿病肾病的关系.方法 选2型糖尿病患者39例,健康体检者21名作为对照,检测血、尿C5a浓度以及血高敏C反应蛋白,测定尿白蛋白排泄率以及血糖控制情况,分析其关系.结果 与对照组比较,2型糖尿病患者尿C5a浓度升高(11.4±21.1 vs 76.3±144.4,P＜0.05),血C5a无明显变化,尿C5a与尿白蛋白排泄率正相关(r＝0.378,P＜0.05),糖尿病病程、尿C5a是尿白蛋白排泄率的独立预测因素.结论 补体活化可能与糖尿病肾病的发生有关.
目的 探討2型糖尿病患者血、尿補體活化片段C5a含量的變化與糖尿病腎病的關繫.方法 選2型糖尿病患者39例,健康體檢者21名作為對照,檢測血、尿C5a濃度以及血高敏C反應蛋白,測定尿白蛋白排洩率以及血糖控製情況,分析其關繫.結果 與對照組比較,2型糖尿病患者尿C5a濃度升高(11.4±21.1 vs 76.3±144.4,P＜0.05),血C5a無明顯變化,尿C5a與尿白蛋白排洩率正相關(r＝0.378,P＜0.05),糖尿病病程、尿C5a是尿白蛋白排洩率的獨立預測因素.結論 補體活化可能與糖尿病腎病的髮生有關.
목적 탐토2형당뇨병환자혈、뇨보체활화편단C5a함량적변화여당뇨병신병적관계.방법 선2형당뇨병환자39례,건강체검자21명작위대조,검측혈、뇨C5a농도이급혈고민C반응단백,측정뇨백단백배설솔이급혈당공제정황,분석기관계.결과 여대조조비교,2형당뇨병환자뇨C5a농도승고(11.4±21.1 vs 76.3±144.4,P＜0.05),혈C5a무명현변화,뇨C5a여뇨백단백배설솔정상관(r＝0.378,P＜0.05),당뇨병병정、뇨C5a시뇨백단백배설솔적독립예측인소.결론 보체활화가능여당뇨병신병적발생유관.
Objective To investigate the relationship between complement C5a and diabetic nephropathy. Methods The concentration of plasma C5a and urine C5a was examined in 39 patients with type 2 diabetes mellitus, 21 healthy volunteers as controls . The relationship between complement C5a and UAER was analyzed. Results Urinary level of C5a was higher in the diabetic nephropathy group than in control （76.3±144.4 vs 11.4±21.1，P=0.046）, Urinary C5a was positively correlated with UAER. The diabetic course and urinary C5a were the independent predictors of urine albumin excretion rate (UAER)（γ=0.378，P=0.023）. Conclusion The activation of complements might involve in the pathogenesis of diabetic nephropathy.
