CAJ | 학술논문

目的观察心衰方对充血性心力衰竭（CHF）患者的临床疗效。方法属NYHA心功能分级为2～3级的门诊及住院患者160例随机分为两组。两组患者均给以病因及对症治疗，对照组按心力衰竭常规处理；治疗组在常规处理的基础上使用心衰方每日一剂分三次服用。观察治疗前后临床症状、体征积分变化；超声心动图指标及运动耐量、生活质量的变化。观察周期共1年。结果（1）两组患者治疗后症状、体征积分均较治疗前降低，治疗组较对照组积分更低（P〈0．05）。（2）治疗组左心室收缩末期容积较治疗前降低，每搏量、有效心输出量、心脏指数、左心室射血分数明显增加与对照组比较差异有统计学意义（P〈0．05），提示心脏的收缩功能改善，心排血量增加。与对照组疗效比较差异有统计学意义（P〈0．05）。（3）治疗组综合疗效总有效率为94．7％，对照组综合疗效总有效率为75％。组间比较差异有统计学意义（P〈0．05）。（4）治疗组的运动耐量、生活质量与对照组比较有较显著提高（P〈0．05）。结论心衰方对充血性心力衰竭具有良好防治作用。
목적관찰심쇠방대충혈성심력쇠갈（CHF）환자적림상료효。방법속NYHA심공능분급위2～3급적문진급주원환자160례수궤분위량조。량조환자균급이병인급대증치료，대조조안심력쇠갈상규처리；치료조재상규처리적기출상사용심쇠방매일일제분삼차복용。관찰치료전후림상증상、체정적분변화；초성심동도지표급운동내량、생활질량적변화。관찰주기공1년。결과（1）량조환자치료후증상、체정적분균교치료전강저，치료조교대조조적분경저（P〈0．05）。（2）치료조좌심실수축말기용적교치료전강저，매박량、유효심수출량、심장지수、좌심실사혈분수명현증가여대조조비교차이유통계학의의（P〈0．05），제시심장적수축공능개선，심배혈량증가。여대조조료효비교차이유통계학의의（P〈0．05）。（3）치료조종합료효총유효솔위94．7％，대조조종합료효총유효솔위75％。조간비교차이유통계학의의（P〈0．05）。（4）치료조적운동내량、생활질량여대조조비교유교현저제고（P〈0．05）。결론심쇠방대충혈성심력쇠갈구유량호방치작용。
Objective： To observe on the clinical curative effect of xinshuaifang on congestive heart failure. Methods： 160 patients of the ambulatory treatment or hospitalization with Ⅱ - Ⅲ cardiac function according to the NYHA cardiac function classification are randomly divided into two groups . The two group are given therapies according to their pathogenesis,the control group are given routine medicine treatment ;based on the routine medicine treatment, the treatment group are given Xinshuanfang treatment, a dose three times a day. Before and after treatment, the clinical symptoms, the score of symptoms, changes of Echocardiography index, exercise tolerance and life quality were observed, the observation period is 1 year. Result：（ 1 ） The clinical symptoms and the score of symptoms and signs of the two groups decreased after the treatment , and the treatment group is even lower than the control group （ P 〈 O. 05）. （2） L~ end - distolic Volume （EDV） of the treatment group decreases after the treatment, Stroke Volume （SV） , cardiac output （CO） , cardiac index （CI） , left ventricular ejection fraction （EF） increase significantly, indicating that the myocardial contractility function is improved and the stroke volume is increased, suggesting significant differences when compared with control group （P 〈 0.05 ）. （3） The total therapeutic effective rate of the treatment group is 94.7% and that of the control group is 75%. There are significant differences between the treatment group and the control group（ P 〈 0.05 ）. （4）There are significant differences between the treatment group and the control group in exercise tolerance life quality （ p 〈 0. 05）. Conclusion： Xinshuaifang has evident curative effect on congestive heart failure.