CAJ | 학술논문

目的观察间歇应用去铁胺对老年人输血相关性铁负荷过重的治疗效果及安全性.方法 23例老年输血相关性铁负荷过重患者应用去铁胺20～50 mg/(kg·d),最大剂量用至2000mg/d,加入0.9%氯化钠500 ml中,持续静脉滴注6 h,每4～6周连续应用5～6 d.结果治疗9个月后,血清铁蛋白从治疗前(2771.5±735.3)μg/L下降到(2483.7±724.4)μg/L(P＜0.01),尿铁蛋白从治疗前(9.68±5.39)μg/L增加到(12.14±5.50)μg/L(P＜0.01).结论间歇应用去铁胺治疗老年人输血相关性铁负荷过重能显著降低血清铁蛋白,且无明显不良反应.
목적 관찰간헐응용거철알대노년인수혈상관성철부하과중적치료효과급안전성.방법 23례노년수혈상관성철부하과중환자응용거철알20～50 mg/(kg·d),최대제량용지2000mg/d,가입0.9%록화납500 ml중,지속정맥적주6 h,매4～6주련속응용5～6 d.결과 치료9개월후,혈청철단백종치료전(2771.5±735.3)μg/L하강도(2483.7±724.4)μg/L(P＜0.01),뇨철단백종치료전(9.68±5.39)μg/L증가도(12.14±5.50)μg/L(P＜0.01).결론 간헐응용거철알치료노년인수혈상관성철부하과중능현저강저혈청철단백,차무명현불량반응.
Objective To evaluate the effect and safety of the intermittent deferoxamine therapy on relieving iron overload caused by transfusion in senile. Method Twenty-three senile with iron overload caused by transfusion were administered in a total daily dose of 20 - 50 mg/ ( kg·d ) for 5 - 6 days per week every 4 -6 weeks,the maximal dose was 2000 mg/d, add in 0.9％ sodium chloride 500 ml, continuous intravenous drip for 6 h. Result Nine months after therapy, serum ferritin fell from (2771.5±735.3)μg/L to (2483.7 ±724.4) μg/L (P＜0.01), and urine ferritin elevated from (9.68 ±5.39)μg/L to (12.14±5.50) μ g/L (P＜0.01 ). Conclusion It shows that intermittent deferoxamine therapy can reduce the serum ferritin with no significant toxicity.