中华麻醉学杂志
中華痳醉學雜誌
중화마취학잡지
CHINESE JOURNAL OF ANESTHESIOLOGY
2008年
12期
1108-1110
,共3页
酰胺类%药代动力学%神经传导阻滞%坐骨神经
酰胺類%藥代動力學%神經傳導阻滯%坐骨神經
선알류%약대동역학%신경전도조체%좌골신경
Amides%Pharmacokinetics%Nerve block%Sciatic nerve
目的 探讨罗哌卡因用于犬坐骨神经阻滞时的药代动力学.方法 成年健康杂种犬12只,雌雄各半,体重14～17 k异,6～8月龄,随机分为2组(n=6),分别采用0.5%罗哌卡因10 mg/kg(A组)和20 mg/kg(B组)行单次坐骨神经阻滞,分别于罗哌卡因给药前、给药后10、20、30、40、60、90、120、150、180、240、360、720 min时抽取股动脉血样5 ml,采用反相高效液相色谱法测定血浆罗哌卡因浓度,监测ECG、BP和HR,记录局麻药毒性反应的发生情况(同时在该点采血测定血浆罗哌卡因浓度).结果 罗哌卡因阻滞犬坐骨神经时的血药浓度-时间曲线符合二室模型,A组血药浓度峰值和曲线下面积低于B组(P<0.01),而其他参数两组间比较差异无统计学意义(P>0.05);各时点HR、SP、DP和MAP差异无统计学意义(P>0.05).B组有2只犬发生惊厥,惊厥时的血药浓度分别为12.56、13.67 mg/L.结论 罗哌卡因用于犬坐骨神经阻滞时的药代动力学特征符合二室模型,大剂量(20 mg/kg)时易产生中枢毒性反应.
目的 探討囉哌卡因用于犬坐骨神經阻滯時的藥代動力學.方法 成年健康雜種犬12隻,雌雄各半,體重14～17 k異,6～8月齡,隨機分為2組(n=6),分彆採用0.5%囉哌卡因10 mg/kg(A組)和20 mg/kg(B組)行單次坐骨神經阻滯,分彆于囉哌卡因給藥前、給藥後10、20、30、40、60、90、120、150、180、240、360、720 min時抽取股動脈血樣5 ml,採用反相高效液相色譜法測定血漿囉哌卡因濃度,鑑測ECG、BP和HR,記錄跼痳藥毒性反應的髮生情況(同時在該點採血測定血漿囉哌卡因濃度).結果 囉哌卡因阻滯犬坐骨神經時的血藥濃度-時間麯線符閤二室模型,A組血藥濃度峰值和麯線下麵積低于B組(P<0.01),而其他參數兩組間比較差異無統計學意義(P>0.05);各時點HR、SP、DP和MAP差異無統計學意義(P>0.05).B組有2隻犬髮生驚厥,驚厥時的血藥濃度分彆為12.56、13.67 mg/L.結論 囉哌卡因用于犬坐骨神經阻滯時的藥代動力學特徵符閤二室模型,大劑量(20 mg/kg)時易產生中樞毒性反應.
목적 탐토라고잡인용우견좌골신경조체시적약대동역학.방법 성년건강잡충견12지,자웅각반,체중14～17 k이,6～8월령,수궤분위2조(n=6),분별채용0.5%라고잡인10 mg/kg(A조)화20 mg/kg(B조)행단차좌골신경조체,분별우라고잡인급약전、급약후10、20、30、40、60、90、120、150、180、240、360、720 min시추취고동맥혈양5 ml,채용반상고효액상색보법측정혈장라고잡인농도,감측ECG、BP화HR,기록국마약독성반응적발생정황(동시재해점채혈측정혈장라고잡인농도).결과 라고잡인조체견좌골신경시적혈약농도-시간곡선부합이실모형,A조혈약농도봉치화곡선하면적저우B조(P<0.01),이기타삼수량조간비교차이무통계학의의(P>0.05);각시점HR、SP、DP화MAP차이무통계학의의(P>0.05).B조유2지견발생량궐,량궐시적혈약농도분별위12.56、13.67 mg/L.결론 라고잡인용우견좌골신경조체시적약대동역학특정부합이실모형,대제량(20 mg/kg)시역산생중추독성반응.
Objective To evaluate the pharmacokineties of ropivacaine for single sciatic nerve block in dogs.Methods Twelve healthy adult mongrel dogs weighing 14-17 kg were randomized to receive 0.5% ropivaeaine 10 mg/kg or 20 mg/kg for single sciatic nerve block(n=6 each).ECG,BP and HR were monitored and recorded during anesthesia.Blood samples were obtained from femoral artery before ropivacaine injection (baseline)and at 10,20,30,40,60,90,120,150,180,240,360 and 720 min after ropivacaine injeetion for determination of plasma ropivaeaine concentration(by reversc-phasc high performance liquid chromatography).Arterial blood samples were also taken when adverse reactions occurred.The pharmacokinetic parameters were eMeulated with DAS 1.0 software package.Results The concentration-time curve of ropivacaine for single sciatic nenre block was fitted to two-compartment open model in both groups.The peak plasma concentration of ropivaeaine was significantly lower in 10 mg/kg group than in 20 mg/kg group.Two dogs developed convulsion in 20 mg/kg group.The plasma ropivaeaine concentration was 12.56 and 13.67 mg/L respectively during convulsion.Conclusion Pharmaeokinetic profile of ropivaeaine for single sciatic nerve block is best described by two-compartment model.Bopivaeaine 20 mg/kg for sciatic nerve block can hardly be tolerated by dogs.
